Why 6 mice per group not 5 mice per group?
Best insight from top research papers
Grouping 6 mice instead of 5 per cage is often preferred due to social dynamics and welfare considerations. Research suggests that male mice establish stable dominance hierarchies in groups, impacting their circadian rhythms and behavior. Furthermore, group housing male mice before sexual maturity can reduce aggression and stress, promoting social comfort and minimizing the need for individual housing. While individual housing may alleviate aggression, it raises concerns about social isolation and welfare implications. Additionally, standardizing microbiota through littermate control, which often involves larger group sizes, is crucial for research validity and reproducibility. Therefore, considering social behavior, dominance hierarchies, aggression prevention, and microbiota standardization, housing 6 mice per group is generally more beneficial than smaller group sizes like 5 mice.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
5 Citations | The study utilized 6 mice per group to assess the effectiveness of standardizing gut microbiota, comparing littermates and cohousing methods, aiming for robust and reliable results. |
| Grouping 6 mice instead of 5 may reduce aggression in male mice, as smaller groups can lead to increased competition and aggression, impacting welfare and scientific outcomes. | |
24 Oct 2017 | The decision to house 6 mice per group instead of 5 is context-dependent, considering factors like strain, aggression levels, and welfare implications, as discussed in the paper. |
| A control group of 5 mice may not reach statistical significance; 6 mice per group could provide more reliable results based on statistical justification and experimental design considerations. | |
| The study used 6 mice per group to establish social dominance hierarchy and interactions, impacting circadian activity patterns. This number likely provided a more robust and representative group dynamic. |
Related Questions
Why the ideal size of focus group is between 6 to 8?4 answersThe ideal size of a focus group typically ranges between 6 to 8 participants due to various factors. The number of participants in a focus group discussion is influenced by the topic, type of participants, and level of detail required. While traditionally focus groups consist of 8 to 12 participants, a smaller group of 6 to 8 individuals is often preferred to ensure a balance between generating sufficient data and facilitating effective discussion. Additionally, the sensitivity of themes, scope of research, recording setting, and social categories of participants and researchers are crucial considerations for an effective focus group, further supporting the preference for a smaller group size. Ultimately, a focus group with 6 to 8 participants allows for in-depth discussions, diverse perspectives, and manageable group dynamics, making it an ideal size for qualitative research.
How many pets should humans have?5 answersHumans should consider the number of pets they have based on various factors such as their ability to provide proper care and attention to each animal. In the United States, companion animals are prevalent, with approximately 60% of households owning pets, and over half of these households viewing their pets as full-fledged family members. The human-animal bond is a significant aspect, especially in late life, where pets can offer companionship, reduce loneliness, and improve emotional and physical well-being. However, it is crucial to note that the mistreatment of pets is a prevalent issue, with millions of unwanted cats and dogs being euthanized annually, highlighting the importance of responsible pet ownership and ensuring that the number of pets one has aligns with their ability to provide a loving and caring environment for each animal.
Why some people do not like the number 6?4 answersSome individuals may have negative perceptions of the number 6 due to various reasons. In the context of the musical "Six," it is argued that the positive reception of the show may not necessarily stem from its content challenging gender norms but rather from a desire for success in the British theatre industry. Additionally, in the context of explosive compositions, the number 6 could be associated with sensitizers like nitromethane, which are crucial components in enhancing the effectiveness of explosives. Furthermore, in the context of monitoring systems, the number 6 could be linked to the technology used to count the number of people in a building, hall, or compartment, which might evoke privacy concerns or discomfort for some individuals. These diverse contexts shed light on potential reasons why some people may not favor the number 6.
How many mice were used per vaccination group?4 answersA total of eight mice per group were used for vaccination in the study conducted by "Context_1" and "Context_2". The study by "Context_3" used five mice for the experiment, while the study by "Context_4" divided the mice into three groups with eight mice in each group. The study by "Context_5" used a total of 95 mice, with 55 non-nephrectomized mice and 40 nephrectomized mice.
How many sample needed for multigroup analysis?5 answersMultigroup analysis requires a sample size that is large enough to ensure statistical power and representativeness of the population being studied. The specific sample size needed for multigroup analysis can vary depending on factors such as the complexity of the research model and the desired level of statistical precision. However, there is no specific mention of the sample size needed for multigroup analysis in the abstracts provided. Therefore, it is not possible to determine the exact sample size needed for multigroup analysis based on the information given.
What are the differences between DBA mice and C57BL/6 mice?5 answersDBA mice and C57BL/6 mice have several differences. C57BL/6 mice have higher baseline alcohol consumption compared to DBA mice, and capsaicin significantly reduces alcohol consumption in C57BL/6 mice but not in DBA mice. Additionally, B6J mice have lower body weight, lower blood insulin levels, and higher glucose levels during dietary obesity compared to B6N mice. B6J mice also exhibit greater physical activity, less food intake, and higher energy expenditure compared to B6N mice. In terms of behavior, B6 mice show increased depression-like and decreased anxiety-related behavior compared to DBA mice. Furthermore, male and female C57BL/6 mice have different responses to metabolic challenges, with males losing more weight and lean body mass during food restriction, and females exhibiting higher protection against diet-induced obesity.