Showing papers on "Anthrax vaccines published in 1987"

Vaccination-related anthrax in three llamas.

Abstract: Two llama calves died 3 days after inoculation with anthrax vaccine. Concurrent administration of ivermectin and other biologics may have enhanced the infectivity of the Sterne strain vaccine of Bacillus anthracis. This experience suggests that the Sterne strain of anthrax vaccine can induce fatal disease when given to young llamas and should be used only with extreme care and in face of strong "at risk" situations.

Protective Efficacy and Safety of Live Anthrax Vaccines for Mice

Abstract: : The safety and protective efficacy of the Sterne vaccine strain of Bacillus anthracis and of a recombinant Bacillus subtilis strain were investigated in mice. Strains of mice which vary in their natural resistance to killing by the Sterne strain were used. Vaccination with Sterne spores protected Sterne-resistant CBA/J mice against challenge with a fully virulent strain of B. anthracis, but only at vaccine doses within a magnitude of the 50% lethal dose (LD50). The Sterne-susceptible A/J mice were not protected. Bacillus subtilis recombinant strain PA2, which produces the protective antigen component of anthrax toxin, protected CBA/J but not A/J mice. Both strains of mice developed high antibody titers to protective antigen. BALB/cJ and CBA/J mice were similarly resistant to lethal Sterne infection, - but BALB/cJ mice were more difficult to protect by immunization with either live vaccine. The inbred mouse model for anthrax is recommended for testing the efficacy and safety of new vaccines and characterizing the mechanisms of immunity to anthrax.