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Showing papers on "Avian Influenza A Virus published in 1983"

Journal Article•
Pathogenesis of neurovirulent influenza A virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells.

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M Reinacher, J Bonin, O Narayan, C Scholtissek
01 Dec 1983-Laboratory Investigation
TL;DR: This recombinant influenza virus could invade the central nervous system after infection via a natural route of infection and provides one example of the extent of virulence which can be acquired by recombination of apathogenic influenza viruses and raises a note of caution for adequate control of those agents generated in the laboratory.

96 citations

Patent•
Human use of avian-human reassortants as vaccines for influenza A virus

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Brian R. Murphy1, Robert M. Chanock1, Robert G. Webster1, V. S. Hinshaw1•
St. Jude Children's Research Hospital1
20 Dec 1983
TL;DR: In this paper, a method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza vaccine parent and then excluding the internal genes (that code for non-surface viral proteins) of the human vaccine parent from the reassortants by temperature selection and excluding the surface antigen genes of the avian Influenza A virus parent by antibodies.
Abstract: A method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza virus parent and then excluding the internal genes (that code for non-surface viral proteins) of the human influenza virus parent from the reassortant by temperature selection and excluding the surface antigen genes of the avian influenza A virus parent by antibodies

24 citations

Patent•
Use in an animal host and precursors for vaccines utilizing avian-human reassortants to combat influenza A virus

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Brian R. Murphy1, Robert M. Chanock1, Robert G. Webster1, V. S. Hinshaw1•
St. Jude Children's Research Hospital1
20 Dec 1983
TL;DR: In this article, a method of producing a vaccine useful in animals which comprises producing a reassortment by gene exchange from an avian influenza A virus parent and an animal influenza A vaccine parent and then selecting for the reassortant containing two animal surface antigen genes and six avian internal genes by temperature and antibodies.
Abstract: A method of producing a vaccine useful in animals which comprises producing a reassortment by gene exchange from an avian influenza A virus parent and an animal influenza A virus parent and then selecting for the reassortant containing two animal surface antigen genes and six avian internal genes by temperature and antibodies.

4 citations