Showing papers on "Benzopyrans published in 2023"

Pd-Catalyzed Denitriative Intramolecular Mizoroki–Heck Reaction

Abstract: A Pd-catalyzed denitrative intramolecular Mizoroki–Heck reaction of nitroarenes with alkenes was developed. Pd/BrettPhos is an effective catalyst for this transformation, producing 5- and 6-membered cyclic products such as indenes and benzopyrans. Since a tethered-alkene group can be introduced onto the nitroarene core through nucleophilic aromatic substitution (SNAr), the present denitrative reaction would provide a convergent synthetic method for benzo-fused cyclic compounds. A Pd-catalyzed denitrative intramolecular Mizoroki–Heck reaction of nitroarenes bearing an alkene was developed. Pd/Brettphos is an effective catalyst, producing 5- and 6-membered cyclic products such as indenes and benzopyrans. Since a tethered-alkene group can be introduced onto the nitroarene core through nucleophilic aromatic substitution (SNAr), the present denitrative reaction would provide a convergent synthetic method of benzo-fused cyclic compounds.