Showing papers on "Beta-thromboglobulin published in 2010"

Effects of time of day and acute resistance exercise on platelet activation and function

Abstract: The present study was designed to ascertain the interaction between time of day and resistance exercise on platelet activation and function. Ten healthy male subjects (age, 29.3 +/- 4.5 yr) undertook identical bouts of resistance exercise on two separate occasions. Tests were randomised and performed at two different time of day (08:00 and 20:00 h). Subjects performed 3 sets of 7 repetitions of six exercises at 80% of 1RM, which was followed by 30 min recovery. Beta-thromboglobulin (B-TG) and platelet indices were measured at rest, post-exercise and at the completion of recovery. Platelet aggregation was determined in platelet rich plasma using collagen and three different concentrations of adenosine-5'-diphosphate. Platelet aggregations induced by different aggregating agents at rest were significantly higher in the morning (p < 0.05). Although platelet aggregations induced by collagen and ADP did not change in response to resistance exercise, significant differences between the results in the morning and evening trials were observed (p < 0.01). These differences emulated the differences observed at rest. A significant (P < 0.05) increase in B-TG was found following exercise with no difference between morning and evening trials. It was concluded that resistance exercise induces significant changes in platelet activation, irrespective of time of day, as assessed by beta-thromboglobulin.

Recovery of platelet factor 4 (PF-4) and beta-thromboglobulin (beta-TG) plasma concentrations during remission in patients suffering from atopic dermatitis.

Abstract: Our previous study has for the first time demonstrated that atopic dermatitis (AD) patients show enhanced plasma concentrations of PF4 and beta-TG. In addition, it has been suggested that chemokines may be the markers of AD severity. The aim of this study was to determine whether enhanced platelet activation in active AD withdraws when the disease reaches the clinical remission stage. Plasma PF-4 and beta-TG concentrations were studied in 10 AD patients and in 23 healthy controls. Patients were examined twice: first, during the active period, and next, during the clinical remission lasting for at least 6 months. Plasma PF-4 and beta-TG concentrations in patients upon AD remission were significantly lower as compared to active AD and did not differ significantly from the healthy subjects. Enhanced platelet activation is a transient phenomenon accompanying active AD and disappears during clinical remission. As with earlier data, the findings point to platelet activity in AD increasing during flare, falling ...