Showing papers on "Biflavonoid published in 1996"
TL;DR: Eighteen natural flavonoids inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.
Abstract: Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.
37 citations
TL;DR: A novel biflavonoid, robustaflavone 4′,7″-dimethyl ether, has been isolated from the leaves of Dysoxylum lenticellare, in addition to two known compounds, isoginkgetin and bilobetin this paper.
25 citations
TL;DR: The biflavonoid pattern of Plagiomnium undulatum has been studied and the new 3‴-desoxydicranolomin, 2,3-dihydro-3‴,3‘- dihydroxyrobustaflavone have been isolated and their structures elucidated spectroscopically.
15 citations
TL;DR: In this paper, the occurrence of eight biflavones belonging to the biluteolin series, the apigenin-lutein series and the 2,3-dihydro-biluteolinseries, and one monomeric flavone with an acid group, was investigated in six taxa of Bartramia with emphasis on sect.Ithyphyllae.
Abstract: The occurrence of eight biflavones belonging to the biluteolin series, the apigenin-luteolin series and the 2,3-dihydro-biluteolin series, and one monomeric flavone with an acid group, was investigated in six taxa ofBartramia with emphasis on sect.Ithyphyllae. The variation of biflavone profiles contributes to the characterization of theBartramia species studied; substitution patterns signalize relevance also on the sectional level. Based upon the flavonoid composition,Bartramia afro-ithyphylla is suggested to be transferred from sect.Ithyphyllae to sect.Bartramia of the genusBartramia.
5 citations
Journal Article•
TL;DR: It was demonstrated that biflavones such as ochnaflavone and ginkgetin inhibited lymphocyte proliferation induced by both concanavaline A and lipopolysaccharide and the inhibition was irreversible in contrast to that of flavones/flavonols.
Abstract: Flavonoids are widely distributed polyphenol compounds in plant kingdom and known to possess varieties of biological/pharmacological activities in vitro and in vivo. A search for antiinflammatory/immunoregulatory flavonoids as potential therapeutic agents has been continued, since serious side effects of currently used nonsteroidal and steroidal antiinflammatory drugs limit their long term uses for the inflammatory disorders. In this reserch, various flavonids were isolated and tested for their in vivo antiinflammatory activity and in vitro inhibitory activity of lymphocyte proliferation. Using a mouse ear edema assay, it was found that certain flavones/flavonols possess mild antiinflammatory activity and a C-2,3-double bond might be essential. Isoflavones were less active. These flavonoids inhibited in vitro lymphocyte proliferation, relatively specific for T-cell proliferation and the inhibition was reversible. We have also tested several biflavonoid derivatives, since we recently found that biflavones were phospholipase inhibitors. It was demonstrated that biflavones such as ochnaflavone and ginkgetin inhibited lymphocyte proliferation induced by both concanavaline A and lipopolysaccharide. The inhibition was irreversible in contrast to that of flavones/flavonols. And antiinflammatory activity of biflavonoids are discussed.
5 citations
01 Jan 1996
TL;DR: In this paper, it was shown that mosses are not primitive embryo-plants, but are closely related to vascular plants, according to their biflavonoid and triflavoneoid composition.
Abstract: In this work we confirm that mosses are not primitive embryo-plants. They are closely related to vascular plants, according to their biflavonoid and triflavonoid composition.
3 citations
3 citations