Showing papers on "Cancer research published in 2002"

Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence.

Abstract: The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of `molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.

Management of Primary Malignant Melanoma

Abstract: Cutaneous malignant melanoma is widely recognized to be multifactorial in its etiology and development (1). There appears to be an increasingly recognized and documented set of causative environmental factors that may be superimposed upon underlying personal genetic substrate factors. Such combinations lead to a predisposition for developing malignant melanoma.