Showing papers on "Chrysanthemum indicum published in 1962"

[studies on antihypertensive drugs. xiii. experimental therapy and toxicity of hc-1, an extract from chrysanthemum indicum].

Abstract: Chrysanthemum indicum is effective in lowering blood pressure. Extraction with hot ethanol yielded an active fraction, HC-1. In anesthetized cats, intraduodenal injetions of 50—100 mg/kg of HC-1 produced an average "％ of hypotensive areas" in 2 hours varying from -19％ to -22％. Four normotensive dogs were fed 50, 100, 130 and 150 mg/kg resp., and the diastolic pressure dropped 0, 24, 8 and 36 mm Hg resp. The hypotensive action was slow and lasted more than 2 hours. Three renal hypertensive dogs were fed daily 100 mg/kg in the first 2 weeks, and 200 mg/kg for the 3rd week. Weekly tests on EKG, serum BSP retention, and blood NPN revealed no serious alterations. In two of them the blood pressure was brought down significantly. Daily feeding of 300 mg/kg to one healthy dog for 3 weeks brought forth no grave reactions except vomiting at times. HC-1 is marked with (a) high yield, (b) low toxicity, (c) mild action, and (d) certain hypotensive effects in anesthetized and unanesthetized animals. So it may be recommended to clinical trial.

[studies on the flavonoids present in chinese drugs. viii. studies on the component of ye-ju-hua, the dry flower of chrysanthemum indicum l].

Abstract: A flavoneglucoside has been isolated from Chrysanthemum indicum L which is identified as acacetin-7-rhamnosidoglucoside and is identical with buddleoglucoside There has also been isolated a crystalline,γ-lactone, mp 213℃, which has the empirical formula C_(15)H_(28)O_4[α]_D~(215)=+225°and vco at 1770 cm~(-1 The respective yields were 072％ and 01％