Showing papers on "Epileptogenesis published in 1969"

Cortical and subcortical secondary epileptogenesis.

Abstract: THE EPILEPTIC SEIZURE may be described as a sudden alteration of function of the nervous system resulting from an abnormal electrical discharge within a population of neural elements. Such an electrical epileptic alteration of function is known to result from a variety of chemical or physical injuries and from hereditary constitutional factors which are not yet completely understood. Electrical alterations, which may represent the pathophysiological substrate of epileptic discharge, have been reported in single cells in the epileptogenic focus as well as in aggregates of In experimental animals and in human beings, epileptiform discharging foci have been observed to occur in neural populations remote from a primary cortical focus,O-13 presumably secondary to synaptic bombardment from the primary lesion. Furthermore, both in experimental animals and human beings, untreated epilepsy may progress in terms of severity, frequency, and complexity. In this light, epilepsy must be considered potentially to represent a dynamic pathophysiological process and not a static unchanging lesion. This study was stimulated by the phenomenon of secondary epileptogenesis. The development of secondary epileptogenic or mirror foci in the contralateral cortical area homotopic to a primary artificially created cortical lesion has been reported by Morrell,\" Wilder and Morrell,7 and Guerrero-Figueroa et aLg Others have described the development of subcortical epileptic discharging foci in areas synaptically related to artificially induced cortical and subcortical epileptic l e s i ~ n s . ~ J ~ These data are the results of an attempt to d e h e subcortical structures and mechanisms involved in the genesis of secondary epileptiform foci. METHOD