Showing papers on "Fatty streak published in 1975"
TL;DR: In this article, the arterial lipid, calcium, and collagen concentrations were determined for squirrel monkeys (Saimiri sciureus), African green monkeys (Cercopithecus aethiops), stump-tailed macaques (Macaca arctoides ), and woolly monkeys ( Lagothrix lagothricha) fed four types of diets with and without cholesterol for 42 months.
34 citations
TL;DR: Histologic features of aortic fatty streaks were examined in male subjects aged 10-39 from Guatemala, Jamaica Negro, Durban Bantu, New Orleans Negro,New Orleans white, Lima and Santiago to imply that the presence of leukocytes and of foci of necrosis in the fatty streak marks its propensity to progress into raised lesions.
27 citations
TL;DR: Investigation of atherosclerotic plaque, fatty streak, and normal tissue from aortas of White Carneau pigeons with naturally-occurring of cholesterol-aggravated atherosclerosis found little increase in collagen content or proline hydroxylase activity occurred, which is consistent with the morphologic observation of the presence of little or no "fibromuscular cap".
14 citations
TL;DR: The ideas on lesion development are outlined, which have evolved on the basis of quantitative chemical and immunochemical studies in human aorta, which may or may not apply to other vessels or other species.
Abstract: I will try to outline the ideas on lesion development which I have evolved on the basis of quantitative chemical and immunochemical studies in human aorta; these findings may or may not apply to other vessels or other species.
5 citations
TL;DR: The results suggested that plasma protein and lipid, especially extracellular lipid, play an important role in developement of atherosclerosis.
Abstract: The authors studied about the distribution and relation between fibrinogen, βlipoprotein and fat droplets in the early phase of human aortic atherosclerosis. The results obtained are as follows : 1) In normal aortic intima : Extracellular fibrillar fat is observed near and along internal elastic fibers. Fibrinogen and lipoprotein fluorescences have no relation with fat depositions. 2) In Grade I lesion (early cloudy thickening of intima) : Fibrinogen and βlipoprotein are diffusely distributed in the upper layer of intima but extracellular fat is observed in the deeper layer of intima. 3) In Grade II lesion : Extracellular amorphous lipid deposition is present along the borderline between original intima and organized mural thrombus. Fibrinogen is diffusely distributed throughout the organized thrombus. βLipoprotein fluorescence is weaker than that of fibrinogen. 4) The fatty streak is composed of accumulation of foamy cells, but fibrinogen and lipoprotein closely correspond with deposition of extracellular lipid. These results suggested that plasma protein and lipid, especially extracellular lipid, play an important role in developement of atherosclerosis.