Showing papers on "Friend leukemia published in 1967"
TL;DR: Administration of concentrated preparations of interferon of high titer inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice.
Abstract: SummaryAdministration of concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice. Interferon was effective only when treatment was continued daily throughout the duration of the experiment, and when inoculated mtraperitoneally (rather than intravenously).We acknowledge with gratitude the excellent assistance of Mile. Chantal Bourali and Mile. Marie-The rese Thomas. Dr. Raymond Latarjet kindly supplied us with the Friend virus and with a large number of Swiss mice which permitted us to start a colony of these mice. We are indebted to Dr. Charles Chany and to Dr. Rebecca Falcoff for discussion and help in preparation of this report, and to Mr. Philippe Lazar and Mrs. Suzanne Gue guen for analyzing our experimental results and aiding us in their presentation. We should like to thank Dr. John F. Enders for reviewing this manuscript and Dr. Sidney Farber for constant en...
74 citations
TL;DR: Interferon inoculated intraperitoneally diffused from the peritoneal cavity into the circulation at a relatively constant rate and a significant level of interferon was maintained in the serum for as long as 5 hours.
Abstract: SummaryVarious factors pertaining to the absence of interferon in the tissues of mice with Friend disease and the passive administration of interferon to mice with Friend disease have been investigated.The diffusion of interferon after intravenous and intraperitoneal inoculation has also been described. After intravenous inoculation the titer of interferon in the serum decreased markedly and interferon was recovered in the urine. Interferon inoculated intraperitoneally diffused from the peritoneal cavity into the circulation at a relatively constant rate and a significant level of interferon was maintained in the serum for as long as 5 hours.We gratefully acknowledge the excellent assistance of Mlle. Chantal Bourali and of Mlle. Marie-The rese Thomas.
33 citations
01 Jan 1967
TL;DR: In this paper, concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice.
Abstract: Summary Administration of concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice. Interferon was effective only when treatment was continued daily throughout the duration of the experiment, and when inoculated mtraperitoneally (rather than intravenously). We acknowledge with gratitude the excellent assistance of Mile. Chantal Bourali and Mile. Marie-Thé rèse Thomas. Dr. Raymond Latarjet kindly supplied us with the Friend virus and with a large number of Swiss mice which permitted us to start a colony of these mice. We are indebted to Dr. Charles Chany and to Dr. Rebecca Falcoff for discussion and help in preparation of this report, and to Mr. Philippe Lazar and Mrs. Suzanne Gué guen for analyzing our experimental results and aiding us in their presentation. We should like to thank Dr. John F. Enders for reviewing this manuscript and Dr. Sidney Farber for constant encouragement and advice.
1 citations