Showing papers on "Histone H4 published in 1915"
Journal Article•
TL;DR: In this paper, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 may be a heritable epigenetic tag of the activated element.
Abstract: The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. AFab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated withFab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element. ActivatedFab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.
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