Showing papers on "Hypoventilation published in 1974"
TL;DR: Pulmonary function studies, particularly of blood gases in conjunction with functional class, may be a significant help in estimating the prognosis and in determining the intensity of acute care in patients in whom pulmonary infection or symptoms of respiratory failure develop.
226 citations
TL;DR: In treating patients with the Pickwickian syndrome, close surveillance, prompt recourse to supported ventilation and prophylactic anticoagulation are mandatory, as unexpected death may occur despite clinical and physiologic improvement.
66 citations
TL;DR: Another infant with congenital failure of automatic ventilation is described; a defective response of the central chemorecepto's to the usual stimuli for respiration was demonstrated, but no specific explanation was found.
60 citations
TL;DR: A syndrome of symptoms including exertional dyspnoea and respiratory tract infection, features of general cerebral dysfunction, and peripheral cyanosis or oedema, was defined and attributed to respiratory insufficiency and correlated with kyphoscoliosis and diaphragmatic paralysis.
Abstract: Fifty-five patients with previous poliomyelitis referred to a rehabilitation unit have been seen for clinical, radiological, and lung function assessment. A syndrome of symptoms including exertional dyspnoea and respiratory tract infection, features of general cerebral dysfunction, and peripheral cyanosis or oedema, was defined and attributed to respiratory insufficiency.
These clinical features correlated with kyphoscoliosis and diaphragmatic paralysis demonstrated radiologically and with abnormalities of lung function. Respiratory symptoms were most obvious in patients with the severest restriction in vital capacity. Neurological symptoms were often related to hypercapnia. The circulatory phenomena however bore no clear relationship to the functional abnormalities nor to the presence of severe lower limb paralysis.
Hypoxaemia, especially in relation to severe kyphoscoliosis, was often induced by ventilation/perfusion imbalance, but there was also evidence of general alveolar hypoventilation due to muscle paralysis.
The value of a simple portable device for ventilatory assistance in these patients has been assessed.
40 citations
TL;DR: Effective clinical screening procedures to distinguish patients with hypoventilation secondary to neuromuscular disorders from patients with medullary respiratory insensitivity include identification of weakness of the muscles used for ventilation by measuring the static maximum inspiratory and expiratory airway pressures.
39 citations
TL;DR: In this paper, the authors described another infant with congenital failure of automatic ventilation; a defective response of the central chemorecepto's to the usual stimuli for respiration was demonstrated, but no specific explanation was found.
31 citations
TL;DR: A 41-year-old slender female who had led an active life presented with heart failure and some months later she became comatose with severe hypercapnia and hypoxemia following a mild sedative and antihistamines.
Abstract: A 41-year-old slender female who had led an active life presented with heart failure Some months later she became comatose with severe hypercapnia and hypoxemia following a mild sedative and antihist
30 citations
TL;DR: A case of encephalitis associated with a remote and occult oat cell carcinoma is presented in which the main clinical features were progressive dementia and central hypoventilation syndrome.
Abstract: A case of encephalitis associated with a remote and occult oat cell carcinoma is presented in which the main clinical features were progressive dementia and central hypoventilation syndrome. The only significant anatomical lesions within the known anatomical substrate of respiration affected the locus caeruleus on both sides. It is speculated that the degeneration of the locus caeruleus was responsible for the central hypoventilation syndrome. Hitherto undescribed neuronal intracytoplasmic eosinophilic inclusions were found in an isolated lesion of the insular cortex. Electron microscopy failed to disclose viral particles in the regions of neuronal degeneration.
24 citations
TL;DR: Recommendations are made for the care of the elderly undergoing major surgery, including the preoperative identification of chronic lung disease, determination of the respiratory reserve, preoperative exercises in deep breathing and coughing for use after operation, adequate oxygenation during the surgical procedure, and close supervision of postoperative respiratory ventilation for the first seventy‐two hours.
Abstract: Postoperative pulmonary complications are a serious danger to any patient who undergoes surgery. The increase in geriatric surgery has brought into focus certain marginal factors that can spell the difference between success and failure. In a series of 300 elderly patients who underwent major surgery at the Henry Ford Hospital, there were 34 in whom clinical and radiologic evidence of atelectasis developed. In 19 others, x-ray examination of the chest showed various infiltrates suggesting pneumonitis, and sputum cultures grew coliform bacteria. Despite appropriate treatment, 5 patients died from postoperative pulmonary complications. Illustrative cases of hypoventilation, atelectasis, pneumonia and pneumothorax are presented. Recommendations are made for the care of the elderly undergoing major surgery, including the preoperative identification of chronic lung disease, determination of the respiratory reserve, preoperative exercises in deep breathing and coughing for use after operation, adequate oxygenation during the surgical procedure, close supervision of postoperative respiratory ventilation for the first seventy-two hours, selective use of mechanical respiratory assistance, and emphasis on early ambulation.
5 citations
TL;DR: In treating patients with the Pickwickian syndrome, close surveillance, prompt recourse to supported ventilation and prophylactic anticoagulation are mandatory, as unexpected death may occur despite clinical and physiologic improvement.
Abstract: Ten patients were observed during 11 episodes of progressive ventilatory failure secondary to gross obesity in a 5 year interval in one hospital. In-hospital mortality was high; seven patients died. Three deaths were related to hypoventilation. Despite effective therapy of ventilatory failure with improvement in clinical status and blood gases, four other patients died, three of pulmonary embolism and one of acute renal failure. In addition, in one surviving patient transitory renal failure developed. In treating patients with the Pickwickian syndrome, close surveillance, prompt recourse to supported ventilation and prophylactic anticoagulation are mandatory. Unexpected death may occur despite clinical and physiologic improvement.
4 citations