Showing papers on "Indole alkaloid published in 1979"
TL;DR: The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin, and the closely related, but less active, 9-methoxycamptethecin was obtained.
Abstract: The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting alkaloids from the indole alkaloid rich Apocynaceae.
102 citations
TL;DR: The monoterpenoid indole alkaloids are a large family of structurally diverse compounds encompassing some of the most important plant medicinais discovered by man as discussed by the authors.
Abstract: The monoterpenoid indole alkaloids are a large family of structurally diverse compounds encompassing some of the most important plant medicinais discovered by man. Although these alkaloids were one of the last major groups of well-known natural products to have their biogenesis delineated, they have become one of the first classes of plant secondary metabolites to be studied at the enzymatic level. A contributory factor has been the excellent progress made by in vivo tracer work, which within a little more than a decade has led to the elucidation of the major features of a highly complicated pathway1,2.
44 citations
TL;DR: The indole alkaloid sitsirikine has been synthesised by a biomimetic conversion of strictosidine and its C-16 configuration established as R by cyclisation to a 16,17-dihydroheteroyohimbine.
7 citations
4 citations