Showing papers on "Levothyroxine Sodium published in 1975"
TL;DR: In a few patients with growth failure without specific clinical signs, diagnosis and differentiation between primary hypothyroidism and primary hypopituitarism can only be made by specific endocrinologic testing.
Abstract: • Five patients with growth failure but few other abnormal clinical signs are presented. Two were shown to have primary hypopituitarism, three had primary hypothyroidism. All received levothyroxine sodium and grew 7.0 to 12.5 cm during the first year and 6.2 to 8.7 cm during the second year of treatment. Three of the adolescent patients developed signs of puberty within six to nine months of initiation of levothyroxine therapy. One hypopituitary patient had femoral epiphysial dysgenesis, hypoglycemia, and undescended testes. One hypothyroid patient had been treated for diabetes mellitus for 8.5 years and may be the youngest patient reported with such a disease combination. We conclude that in a few patients with growth failure without specific clinical signs, diagnosis and differentiation between primary hypothyroidism and primary hypopituitarism can only be made by specific endocrinologic testing. (Am J Dis Child129:1397-1399, 1975)
1 citations
TL;DR: As thyroxine probably does have biological activity not dependent on conversion to T 3 , 1 the more prolonged exposure to levothyroxine after high intravenous dosage may be needed.
Abstract: In Reply.— We thank Doctors Green and Graham for their comments. Although the total body pool of thyroxine is approximately 500μg to 800μg, we have been reluctant to give a comatose patient more levothyroxine sodium than 200μg to 250μg as an intravenous bolus because of the disposal rate of thyroxine which is about 10% in 24 hours and the possibility of an accumulation of the hormone. We have had a few patients in whom cardiac arrhythmias developed at higher doses, which, of course, may also have occurred had lower doses been administered. This is interesting, as we have not encountered problems with relatively higher doses of liothyronine sodium. The responses probably reflect different disposal rates and patient sensitivity to thyroxine and triiodothyronine (T 3 ). As thyroxine probably does have biological activity not dependent on conversion to T 3 , 1 the more prolonged exposure to levothyroxine after high intravenous dosage may