Showing papers on "Palmoplantar pustulosis published in 1985"

Palmoplantar pustulosis and smoking.

Abstract: A multicentre case-control study of 216 patients with palmoplantar pustulosis and 626 controls with miscellaneous dermatoses showed a considerably higher prevalence of smoking in the group with palmoplantar pustulosis. This was the first indication that smoking may be an important factor in this skin disease, possibly by affecting the inflammatory responses of the skin.

The effect of etretinate compared with different regimens of PUVA in the treatment of persistent palmoplantar pustulosis.

Abstract: Eighty-four patients with persistent palmoplantar pustulosis (PPP) of long duration were treated with either etretinate or one of three PUVA regimens. PUVA was given either with oral methoxsalen (thirteen cases), with a 1% methoxsalen cream (thirty-three cases) or with trioxsalen baths (eighteen cases). Twenty patients were treated with etretinate. Patients were assessed every fourth week. A mean score for each group was calculated at each visit based on erythema, desquamation, induration and pustulation. In addition, the number of pustules was calculated at each visit. After 12 weeks four of twenty-eight patients treated with local methoxsalen and fourteen of seventeen patients treated with etretinate had completely cleared. At this stage no patient treated with local trioxsalen or oral methoxsalen showed complete clearance.

Anterior thoracic and intervertebral erosive joint diseases associated with palmoplantar pustulosis

Abstract: The authors report three cases of palmo-plantar pustulosis associated with articular signs: erosive arthritis of the right first sternocostal joint in 2 cases (without hypertrophy of the clavicle or the sternum) and atlanto-occipital arthropathy with marked neck stiffness in another case. The HLA phenotype of one case was: A2 - A9 - B14 - X - DR3 - DR4. A surgical sterno-costal biopsy revealed non-specific inflammatory lesions in 2 cases. In one of these cases, a Corynebacterium sp. was isolated. The clinical course was favourable in response to local antibiotic therapy in one case (follow-up of 8 years) and after treatment with non-steroidal anti-inflammatory agents in 2 cases (follow-up of one to two years). The skin biopsy revealed non-spongiform (and therefore non-psoriatic) unilocular pustulosis, distinguishing this non-bacterial pustulosis from pustular palmo-plantar psoriasis with which it is frequently confused. These cases are similar to the cases of "pustulotic arthro-osteitis" reported by Japanese authors (Sonozaki et al.), which appear to be rare in Europe. They seem to be an early form in a vast range of spondylo-arthropathies including rheumatism and acne conglobata. The aetio-pathogenesis of this syndrome is discussed; one of the cases is strongly suggestive of an infectious origin (Corynebacterium). These lesions do not appear to be a form of reactive arthritis, as the presence of HLA B27 is rare in both the European and the Japanese cases.

PUVA therapy for palmoplantar pustulosis

Abstract: Forty patients suffering from pustulosis palmoplantaris were treated with PUVA therapy. Thirty-six patients had palmar lesions which cleared in 31 cases; in 18 cases after an initial course of 3 sessions of treatment per week during an average period of 10 weeks, and in another 13 only after additional, less frequent continuation of the PUVA therapy. The average total UVA dose at clearing of the palmar lesions was 191 and the final UVA dose 7.3 J/cm2. After 2 years, 9 out of the 31 cases of palmar lesions were still completely healed, and the average duration of remission was greater than or equal to 15 months. For plantar lesions the results of PUVA therapy, using essentially the same procedure, were less satisfactory: healing being obtained in only 5 out of 34 cases. However, for palmar and plantar lesions alike, most patients have reported long-standing improvement from PUVA therapy. A surprisingly high frequency of nausea was noted as a side-effect.

Acute palmoplantar pustulosis.

Abstract: SUMMARY This paper describes five cases of an uncommon acral rash, acute palmoplantar pustulosis, which is precipitated by infection, and may represent a true pustular bacterid. Acute and chronic palmoplantar pustulosis are probably different forms of the same disease, but the prognosis in the acute form is good and aggressive therapy is not indicated. The relationship to psoriasis is discussed.

Vertebral and thoracic osteoarticular manifestations in palmoplantar pustulosis

Abstract: Two cases of inflammatory joint disease during attacks of aseptic palmo-plantar pustulosis are reported. Both patients had vertebral involvement: disco-vertebral erosions at several levels in one case and spondylitis and intersomatic ossification in the other. One patient also had sacroiliitis and involvement of the anterior thoracic skeleton (costoclavicular joints, costal cartilages ans xiphoid) confirmed by bone scintigraphy. The relation between this cutaneous-articular syndrome and other inflammatory joint diseases, especially ankylosing spondylitis and psoriatic arthropathy are discussed. The very unusual involvement of the anterior thoracic skeleton, the coexistence of aseptic palmo-plantar pustulosis and absence of antigens HLA B27, B13 and B17 suggest a similarity to the pustular osteoarthritis recently described by Japanese workers who grouped this condition with other spondylarthropathies.

Palmoplantar pustulosis and smoking

Abstract: 1 Greer IA, Walker JJ, McLaren M, Calder AA, Forbes CD. A comparative study of the effects of adrenoreceptor antagonists on platelet aggregation and thromboxane generation. Thromb Haemost 1985;54:480-4. 2 Greer IA, Walker JJ, Calder AA, Forbes CD. Inhibition of platelet aggregation in whole blood by adrenoceptor antagonists. Thromb Res (in press). 3 Greer IA, Walker JJ, Calder AA, Forbes CD. Aspirin with an adrenergic or a calcium channel blocking agent as new combination therapy for arterial thrombosis. Lancet 1985;i: 351-2. 4 Persantine-Aspirin Reinfarction Study II Research Group. Persantine-Aspirin reinfarction study. Part II secondary coronary prevention with persantine and aspirin. Circulation (in press). 5 Beaufils M, Uzan S, Donsimon R, Colan JC. Prevention of preeclampsia by early anti-platelet therapy. Lancet 1985;i:840-2. 6 Goodman RP, Killam AP, Brash AR, Branch RA. Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension. AmJ Obstet Gynecol 1982;142:817. 7 Greer IA, Walker JJ, Cameron AD, McLaren M, Calder AA, Forbes CD. A prospective longitudinal study of immunoreactive prostacyclin and thromboxane metabolites in normal and hypertensive pregnancy. Clinical and Experimental Hypertenswn. (Part B-Hypertension in Pregnancy) (in press).

Palmoplantar pustulosis and smoking

Abstract: psoriasis NS; Student's t test). At present a sex and smoking matched control group is not available for comparison with the patients with palmoplantar pustulosis, but there was no difference between results for smokers and non-smokers within the three groups of subjects. Our study has shown similar results of assessment of neutrophil morphology in palmoplantar pustulosis and psoriasis. Abnormalities of neutrophil C3b receptor function in the two disorders have also been reported to be similar,6 although this may not be the case for intralesional neutrophils.7 Although our preliminary results suggest that peripheral blood neutrophil morphology is not changed by cigarette smoking, further studies of the relation between psoriasis, palmoplantar pustulosis, smoking, chemoattractant production, and neutrophil function are certainly warranted to explain the epidemiological findings reported by Dr O'Doherty and Ms Macintyre. NEIL H Cox SIMON RAY

Treatment of palmoplantar pustulosis with Chinese herbal and crude drugs.

Abstract: 掌蹠膿疱症は慢性に経過する難治性の疾患である。本症の発症機序に病巣感染アレルギーが関与していると考えられているが, その本態となるといまだに不明である。したがつて本症の治療は感染病巣の治療をはじめ多岐にわたつており, 決定的なものがないのが実情である。著者は漢方薬により掌蹠膿疱症5例の治療を試みた。結果は著効2例, 有効1例, 無効2例であつた。有効であつた薬方は十味敗毒湯加ヨク苡仁, 麻杏ヨク甘湯, 加味逍遙散加ヨク苡仁であつた。これまでのところ掌蹠膿疱症に対し病名投与をしうる薬方はなく, 患者の証に合致した薬方を選択することが必要であると考えた。