Showing papers on "Papillary thyroid cancer published in 1987"
TL;DR: This report from the Canadian survey of thyroid cancer describes 1,074 patients with papillary thyroid cancer and 504 with follicular thyroid cancer followed for four to 24 years, and univariate analysis of 12 possible prognostic factors demonstrated that nine were of statistical significance.
368 citations
TL;DR: In a recently completed study 2 of 859 patients with PTC, treated at the Mayo Clinic, Rochester, Minn, during a 25-year period and followed for up to 39 years, 11 patients with brain metastases were identified and one patient was found to have brain metastasis 33 years after the initial report.
Abstract: To the Editor. —In their recent article, Parker et al 1 stated that distant metastasis in cases of papillary thyroid cancer (PTC) typically involves "the lung, bone, or liver" and, in reviewing 1346 reported PTC cases, they found only two (0.15%) examples of brain metastasis. In a recently completed study 2 of 859 patients with PTC, treated at the Mayo Clinic, Rochester, Minn, during a 25-year period and followed for up to 39 years, 11 patients (1.3%) with brain metastases were identified. In 40 patients developing postoperative metastasis, the principal sites of involvement were lungs (70%), mediastinum (24%), bone (23%), and brain (15%). Of 56 patients dying of PTC, 11 patients (20%) died as a consequence of metastasis to the brain or the spinal cord. Both of the patients described by Parker et al 1 were males; one patient was found to have brain metastasis 33 years after the initial
19 citations
TL;DR: Since lethal outcome was seen even in cases lacking the aforenamed unfavourable criteria, total thyroidectomy should be performed for all widely invasive neoplasms regardless of cellular or histological differentiation, stage of disease and age at diagnosis.
Abstract: A retrospective study of 202 papillary thyroid carcinomas was conducted to determine the prognostic value of different morphological and clinical features. The biological behaviour was primarily influenced by tumor type: Among encapsulated (n = 28) and occult lesions (n = 34), each time recurrence-free survival was seen, whereas 22% of patients with widely invasive tumours (n = 140) died from carcinoma (mean observation period: 9.6 years). In the latter group, dismal prognosis was demonstrated for older patients (greater than 52 years) and oxyphilic or poorly differentiated tumours; the same effect was shown for presence of distant haematogenous spread and tumour invasion of cervical soft tissue. Since lethal outcome was seen even in cases lacking the aforenamed unfavourable criteria, total thyroidectomy should be performed for all widely invasive neoplasms regardless of cellular or histological differentiation, stage of disease and age at diagnosis. The same applies for the two prognostically excellent subtypes in the case of regional metastases. As opposed to this, hemithyroidectomy and life-long TSH-suppressive oral hormone replacement therapy is regarded to be sufficient in encapsulated and occult papillary tumours not accompanied by regional or distant metastases.
7 citations