Showing papers on "Phagosome published in 1967"
TL;DR: The change in location of small phagosomes containing ingested horseradish peroxidase was investigated as a function of time after injection and dose and a new formation of lysosomes in these cells seemed to take place in relation to the digestion of peroxIDase, suggesting the transformation of endothelial cells into Kupffer cells.
Abstract: The change in location of small phagosomes containing ingested horseradish peroxidase was investigated as a function of time after injection and dose. A spread of small phagosomes from the apical toward the basal poles was observed in the tubule cells of the kidney during the first 30 min after injection of peroxidase. In the proximal convoluted tubule cells, many small phagosomes were seen lying close to lysosomes, 15-30 min after protein injection, probably preceding fusion. Small phagosomes almost disappeared from the cells when their fusion with lysosomes was completed. In the distal tubule cells the, main transport of peroxidase occurred between the apical and basal regions, and only a minor part was transported to lysosomes. At greatly reduced loads, the cells of the proximal convoluted tubules and large collecting tubules continued to absorb the protein but peroxidase transport across the distal tubule cells was abolished. Phagosomes in glomerular epithelial cells were observed only when optimal co...
41 citations
TL;DR: Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus, an intracellular digestive system comparable, except for its discontinuity, to the digestive tract of higher organisms.
Abstract: Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive system comparable, except for its discontinuity, to the digestive tract of higher organisms. Each vacuole is to some extent equivalent to a certain segment of this digestive tract.
17 citations