Showing papers on "Protein Z published in 1995"
TL;DR: Protein Z deficiency is described as a new type of bleeding tendency in patients with bleeding tendency of unknown origin, who were not under oral anticoagulant treatment and had normal liver synthesis function.
58 citations
TL;DR: Severe diminutions of blood plasma protein Z were found in patients with chronic liver diseases, indicating that protein Z primarily originates from the liver.
Abstract: Protein Z is a vitamin K-dependent plasma protein, which promotes the association of thrombin with phospholipid surfaces. Deficiency states of protein Z have recently been shown in patients with a bleeding tendency of an otherwise unknown origin. In the present study severe diminutions of blood plasma protein Z were found in patients with chronic liver diseases. Protein Z levels decreased with increasing severity of liver disease. Strong correlations between protein Z and other plasma proteins of liver origin indicate that protein Z primarily originates from the liver. The cutaneous bleeding tendency in cirrhosis may in part be due to protein Z deficiency.
29 citations
13 citations