Showing papers on "Ribostamycin published in 1980"

Inhibition of candidacidal activity of human neutrophil leukocytes by aminoglycoside antibiotics.

Abstract: We have tested the effect of five aminoglycoside antibiotics (gentamicin, sisomicin, tobramycin, ribostamycin, and amikacin) on the candidacidal activity of human neutrophils in vitro; all of them are inhibitory and can be grouped into three significantly different levels of toxicity. Gentamicin in the most toxic and sisomicin is the least toxic.

Isolation of an intermediate of 2-deoxystreptamine biosynthesis from a mutant of Bacillus circulans.

Abstract: Eight 2-deoxystreptamine-negative (DOS-) mutants were isolated from various strains of Bacillus circulans, normally producing butirosin, xylostasin and ribostamycin. These mutants were classified into two groups (converter and secretor) by the simple method of cosynthesisusing agar plate culture. One of the cosynthetic pairs, strain S-11 and strain 236, was selected for further study From the fermentation broth of strain S-11, an intermediate of DOS biosynthesis, S-11-P, was isolated. This compound was converted to butirosin (BTN) effectively by strain 236. The structure of S-11-P was considered to be (1 L or 1 D)-1, 3, 5/2, 4-5-amino-cyclohexanetetrol, and the pathway of DOS biosynthesis is discussed here.

Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.

Abstract: 2',3'-Epimino analogues of neamine, ribostamycin, and kanamycin B possessing little or no intrinsic antimicrobial activity were designed to enhance the activity of kanamycin A against bacterial strains that elaborate aminoglycoside 3'-phosphotransferases. Routes were devised for their synthesis from the parent antibiotics and the 2'',3''-epimino analogue of kanamycin B also was prepared. None of these analogues was active against phosphotransferase-producing bacteria, although the kanamycin B derivatives showed very weak activity against nonresistant strains. At 8 and 32 microgram/mL, the 2',3'-epimino analogue of neamine produced a small synergistic effect on the activity of kanamycin A against a strain of Escherichia coli that produces aminoglycoside 3'-phosphotransferase II. The N3-(carbobenzyloxy) derivative of this analogue produced a small effect against the same strain, and it, as well as the 2'',3''-epimino analogue of kanamycin B, slightly enhanced the activity of kanamycin A against a strain of Proteus rettgeri that elaborates a similar enzyme.

The Total Synthesis of Neomycin C

Abstract: The total synthesis of the pseudo-tetrasaccharides antibiotic neomycin C is described, involving condensation of 6,3′,4′,5″-tetra-O-acetyl-1,3,2′,6′-tetra-N-(benzyloxycarbonyl)ribostamycin with 3,4-di-O-acetyl-2-deoxy-2-(p-methoxybenzylideneamino)-6-O-tosyl-α-D-glucopyranosyl bromide by a modified Koenigs-Knorr reaction.

Pharmacokinetics of ribostamycin in healthy volunteers and patients with impaired renal function.

Abstract: Ribostamycin is an aminoglycoside antibiotic produced by Streptomyces ribosidificus, and extracted and isolated by NIIDA et al It has been used widely clinically with its characteristic of low ototoxicity UMEMURA et al studied the pharmacokinetics of this antibiotic in animals and reported that it has a similar pharmacokinetic behavior in vivo to kanamycin In the present studies, the pharmacokinetic behavior of ribostamycin was studied in 5 healthy adult volunteers receiving different doses (05 g, 10 g and 15 g) by intramuscular injection, and 05 g by intravenous drip infusion In addition, a similar study was conducted with 11 patients with varying degrees of renal dysfunction in order to study the application of ribostamycin in such patients

Ribostamycin in chronic and recurrent bronchopulmonary and urinary infections

Abstract: Results in the treatment of mostly Gram-negative infections of the respiratory apparatus (30 subjects) and the urinary apparatus (20 subjects) with ribostamycin are reported. These were regarded as good overall, as shown by the bacteriological findings. An extremely high sensitivity to the antibiotic was noted in isolated germs from both types of infection. This good response in vitro was matched by an equally encouraging bacteriological result in vivo.

Inhibitory Effects of Aminoglycoside Antibiotics on Reduction of Cytochrome c from Candida krusei

Abstract: Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM greater than RSM greater than PRM. As this order correlated closely with that of the antibacterial activity of AGAs, Yamabe's system has proved useful in predicting the latter activity. Divalent metal ions other than Fe2+ enhanced the AGA-dependent inhibition of Yamabe's system in the order: Cu2+ greater than Mn2+ greater than Zn2+ greater than Co2+ greater than Ni2+ greater than. This order was similar to that of stability constants with general chelators except for the low positions of Ni2+ and Co2+. These findings suggested a metal chelation with free or bound Fe2+ for the action mechanism of AGAs on Yamabe's system and the bacterial growing system. The antagonistic effects of exogenous Fe2+ on the antibacterial activity against Staphylococcus aureus and Escherichia coli as measured by the agar dilution method supported this concept. A dual relationship of molecular structure with chelating and antibacterial activities demonstrated the importance of high molecular basicity in a potent AGA. However, the combination effect of pipemidic acid (stimulator on Yamabe's system) with KM was different from that with 1,10-phenanthroline (inhibitor on Yamabe's system) as measured by Dye's method using Pseudomonas aeruginosa.