Showing papers on "Sodium propionate published in 1981"
TL;DR: Treatment of a cloned mastocytoma P-815 cell line with 1 mM-sodium n-butyrate for 40h induced prostaglandin synthase activity and arrested cell growth, and selective induction of fatty acid cyclo-oxygenase activity by sodium n- butyrate was suggested.
Abstract: Treatment of a cloned mastocytoma P-815 cell line (2-E-6) with 1 mM-sodium n-butyrate for 40h induced prostaglandin synthase activity and arrested cell growth. The induction of enzyme activity by n-butyrate was not associated with suppression of DNA synthesis, since hydroxyurea had no effect on prostaglandin synthase induction. The effect of sodium n-butyrate was reversible. Experiments with cycloheximide and actinomycin D showed that the induction of prostaglandin synthase activity involved synthesis de novo of protein and RNA. The time of half-maximal induction of the newly synthesized RNA for prostaglandin synthase activity was estimated as about 15h, which is similar to the generation time of the cells. Selective induction of fatty acid cyclo-oxygenase activity by sodium n-butyrate was suggested by the following two pieces of experimental evidence. (1) There was no significant difference between treated and untreated cells in the activities of radioactive prostaglandin H2 conversion into individual prostaglandins. (2) The incorporation of [3H]acetylsalicylic acid into the fraction equivalent to protein of mol.wt. approx. 75000 of sodium n-butyrate-treated cells was higher than that of untreated cells, on analysis of cell particulate fraction by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. A high concentration (5 mM) of sodium propionate also induced prostaglandin synthesis, but other short-chain fatty acids, such as isobutyrate and sodium acetate, had no effect.
17 citations
Patent•
30 Apr 1981
TL;DR: In this article, the authors used a C2-8 aliphatic carboxylic acid to prevent and treat diarrhoea (scour) in calves, which was used for prevention and treatment of colorectal cancer.
Abstract: Rehydrating compsns. contg. glucose, an amino acid which may be a salt, and a sodium salt of a C2-8 aliphatic carboxylic acid, and, opt. magnesium, potassium and bicarbonate ions, are new. Suitable amino acids include sodium glutamate, sodium aspartate, glycine and alanine. Suitable acid salts include sodium acetate and sodium propionate. If the compsns. are to be administered orally, they have a pH between 7.2 and 7.6 and pref. contain 60-100 mMoles/litre glucose, 20-40 mMoles/litre sodium glutamate and 40-60 mMoles/litre sodium acetate. If given intravenously, the compsns. have a pH above 7.6 and pref. contain 60-100 mMoles/litre glucose, 5-20 mMoles/litre sodium glutamate and 20-40 mMoles/litre sodium acetate. Used for prevention and treatment of diarrhoea (scour) in calves.
12 citations
Patent•
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TL;DR: An improved water-soluble tablet was disclosed in this paper, which includes either a combination of polyethylene glycol and sodium propionate, or a mixture of the two ingredients.
Abstract: An improved water-soluble tablet is disclosed. The tablet includes sodium propionate or a combination of sodium propionate and polyethylene glycol.
6 citations
Patent•
05 Feb 1981
TL;DR: In this article, a new mineral-rich feed supplement consists of or contains a combination of a propionic acid salt and digested starch or starch-like products, which prevents or reduces fertility disorders such as cysts and retained placenta, thus avoiding the need for treatment with e.g. hormones or hormone releasing factors.
Abstract: New mineral-rich feed supplement consists of or contains a combination of (A) a propionic acid salt and (B) digested starch or starch-like products. The pref. propionic acid salt is sodium propionate, which is pref. used in an amount of 10 wt. parts per 2-100 wt. parts digester starch. The feed supplement advantageously contains usual additives such as vitamins, trace elements, inorganic cpds. of Ca, P, Na and Mg and/or propylene glycol. When administered to cows, the new feed supplement prevents or reduces fertility disorders such as cysts and retained placenta, thus avoiding the need for treatment with e.g. hormones or hormone releasing factors.
5 citations
31 Oct 1981
TL;DR: It was found that about 10 per cent of the radioactivity in the liver at three days after administration was incorporated into glycogen, and theRadioactivity found in the lipid fraction amounted to 29 and 80% of the totalRadioactivity in skin and adipose tissue, respectively.
Abstract: In order to investigate the metabolism of sodium propionate in rats, respiratory expiration, urinary and fecal excretion and tissue distribution were studied after single oral administration of [2-14C] sodium propionate. The expiration of 14CO2 was rapid, and a half of the radioactivity administered was expired within 4 hours. The amount of radioactivity expired during three days was 77 per cent. About 7 per cent of the radioactivity administered was excreted in feces and urine during three days, of which unchanged 14C-propionate accounted for only a trace. Relatively high levels of radioactivity were observed in skin, liver, intestine and adipose tissue at three days after administration. The amounts of radioactivity distributed to these tissues were 3.9, 1.1, 0.9 and 0.7 per cent, respectively. There were no marked differences among the concentrations of radioactivity in all examined organs, including the above-mentioned tissues. It was found that about 10 per cent of the radioactivity in the liver at three days after administration was incorporated into glycogen. The radioactivity found in the lipid fraction amounted to 29 and 80 per cent of the total radioactivity in skin and adipose tissue, respectively.
3 citations
TL;DR: In this paper, field desorption mass spectra of sodium acetate and sodium propionate, labelled analogs, and mixtures were used to investigate hydrogen and alkyl group exchange accompanying the de-sorption process.
Abstract: Field desorption mass spectra of sodium acetate and sodium propionate, labelled analogs, and mixtures were used to investigate hydrogen and alkyl group exchange accompanying the desorption process. At low anode temperatures, decomposition products are minimized and formation of homologous carboxylates by alkyl transfer is significant. The complexity of these intermolecular reactions precludes a simple mechanistic scheme. Reproducibility of minor ions is much improved by the addition of pentaerythritol to these samples.
2 citations
TL;DR: The body weight gain, the values in hematological and serum biochemical examinations, the organ weights and the pathological findings indicated that there was no potentiation of toxicity in the combination of SS and SP.
Abstract: Toxicological potentiation of two food additives was investigated in male and female Wistar rats given sodium sulfite (SS) and sodium propionate (SP) in the diet for 3 months. The concentrations of the samples in the diet were 0 (control), SS 1, 2 and 4%, SP 1.25, 2.5 and 5%, SS 2%+SP 2.5%, SS 2%+SP 5% and SS 4%+SP 2.5%. The body weight gain, the values in hematological and serum biochemical examinations, the organ weights and the pathological findings indicated that there was no potentiation of toxicity in the combination of SS and SP.
1 citations
Journal Article•
1 citations