Showing papers on "Super oxide dismutase published in 1991"
TL;DR: Copper supplementation effects on cholesterol deserves further investigation, as differences in cholesterol may be partly explained by variability in the placebo groups in both studies.
Abstract: Two 6-wk double-blind studies evaluated the effects of supplements of 2 or 3 mg Cu/d on serum copper, ceruloplasmin, red-blood-cell super oxide dismutase (RBC-SOD), total serum cholesterol, and serum lipoprotein-cholesterol fractions in adult males. Study I had 6 supplemented and 8 placebo subjects, whereas study II had 7 and 6, respectively. Copper supplementation did not appear to affect serum copper levels, RBC-SOD, hematocrit, and ceruloplasmin levels when assayed by radial immunoassay diffusion. Supplementation with 2 mg Cu/d produced an increase in LDL cholesterol and the percentage of cholesterol as LDL at wk 4 compared to the placebo group, and a concomitant decline in VLDL-cholesterol levels and the percentage of cholesterol as VLDL. At wk 6, the percentage of cholesterol as LDL increased and that of cholesterol as VLDL decreased compared to baseline values in the supplemented group. Supplements of 3 mg Cu/d increased hemoglobin levels ceruloplasmin activity, and serum total-cholesterol levels at wk 6 compared to placebos. Differences in cholesterol may be partly explained by variability in the placebo groups in both studies. Copper supplementation effects on cholesterol deserves further investigation.
24 citations
01 Jan 1991
TL;DR: The interaction of chlorophyll a with superoxide anion was studied in an alkaline DMSO-water system and the allomerization reaction was found to be inhibited by superoxide dismutase.
Abstract: The interaction of chlorophyll a with superoxide anion was studied in an alkaline DMSO-water system. It was found that O2, directly or via HO2, produces the chlorophyll enolate-ion (Molish's intermediate) that is oxidized to Mg-chlorine(s). The allomerization reaction was found to be inhibited by super oxide dismutase. A possible participation of oxygen radicals in chlorophyll degradation in plants is discussed.
4 citations
Patent•
30 May 1991
TL;DR: A preparation for hypodermic administration containing human Cu or Zn-SOD and a pharmaceutically acceptable carrier (e.g. distilled water for injection) is described in this article.
Abstract: PURPOSE:To obtain a preparation for hypodermic administration maintaining stable blood concentration for many hours, containing human super oxide dismutase(SOD) and carrier. CONSTITUTION:A preparation for hypodermic administration containing human Cu or Zn-SOD and a pharmaceutically acceptable carrier (e.g. distilled water for injection). By hypodermic administration, durability of blood concentration is more improved than that by intravenous injection and excellent treating effects on ischemic disorder such as ischemic myocardial necrosis, edema, arrhythmia, blood circulation disorder, etc.
1 citations
Patent•
04 Mar 1991
TL;DR: In this article, a plant cell is treated with a specific salt at the early time of the culture and a resistant cell is transplanted into a medium not containing the salt to improve the multiplication degree of the callus.
Abstract: PURPOSE:To prepare a plant culture cell efficiently producing a plant having a high super oxide dismutase activity by treating a plant cell with a specific salt at the early time of the culture and subsequently transplanting a resistant cell thus induced into a medium not containing the salt. CONSTITUTION:When a cell having a high super oxide dismutase activity is induced from a plant culture cell, the plant culture cell is treated with a high concentration of 1,1'-dimethyl-4,4'-bipyridinium salt (PQ) at the early time of the culture to induce a PQ-resistant cell in a high concentration in a short time. The induced cell is transplanted into a medium not containing the PQ. The activity-enhancing method has the following characteristics. (i) The PQ- resistant callus is simply prepared in a high concentration only by culturing the plant culture cell in medium containing the PQ in a high concentration. (ii) The SOD activity of the cell is further enhanced by transplanting the PQ- resistant cell into the medium not containing the PQ, and the improvement of the multiplication degree of the callus and the preparation of the PQ-resistant callus in a high concentration are achieved.
1 citations