Showing papers on "Swertia published in 1985"

Swertia japonica herba extract and production thereof

Abstract: PURPOSE: To obtain the titled extract containing swertiamarin and oleanolic acid useful as a drug effect components, by extracting swertia japonica herba with ethanol in a specific concentration. CONSTITUTION: Swertia japonica herba is extracted with an aqueous solution of ethanol in 70W90vol% concentration in a volume of 6W20 times based on the weight of the dried swertia per extracting operation to give a sertia japonica herba extract containing ≥20mg swertiamarin based on 1g dried weight of the swertia japonica herba and ≥6mg oleanolic acid based on 1g dried weight of the swertia herba. Although the swertia japonica herba extract contains swertiamarin which is a water-soluble active constituent and oleanolic acid which is a water-insoluble active constituent in high contents, the composition of the extract components is changed depending on the kind or concentration of alcohol used as an extraction solvent. The use of the aqueous solution of the ethanol in the above-mentioned concentration provides the swertia japonica herba extract containing both active constituents. COPYRIGHT: (C)1987,JPO&Japio