Showing papers on "Tartrazine published in 1981"
TL;DR: Seventeen commonly used dyes and 16 of their metabolites or derivatives were tested in the Salmonella-mammalian microsome mutagenicity test and none of them were mutagenic.
Abstract: Seventeen commonly used dyes and 16 of their metabolites or derivatives were tested in the Salmonella-mammalian microsome mutagenicity test. Mutagens active with and without added Aroclor-induced rat liver microsome preparations (S9) were 3-aminopyrene, lithol red, methylene blue (USP), methyl yellow, neutral red, and phenol red. Those mutagenic only with S9 activation were 4-aminopyrazolone, 2,4-dimethylaniline, N,N-dimethyl-p-phenylenediamine, methyl red, and 4-phenyl-azo-1-naphthylamine. Orange II was mutagenic only without added S9. Nonmutagenic azo dyes were allura red, amaranth, ponceau R, ponceau SX, sunset yellow, and tartrazine. Miscellaneous dyes not mutagenic were methyl green, methyl violet 2B, and nigrosin. Metabolites of the azo dyes that were not mutagenic were 1-amino-2-naphthol hydrochloride, aniline, anthranilic acid, cresidine salt, pyrazolone T,R-amino salt (1-amino-2-naphthol-3,6-disulfonic disodium salt), R-salt, Schaeffer9s salt (2-naphthol-6-sulfonic acid, sodium salt), sodium naphthionate, sulfanilamide, and sulfanilic acid. 4-Amino-1-naphthalenesulfonic acid sodium salt was also not mutagenic. Fusobacterium sp. 2 could reductively cleave methyl yellow to N,N-dimethyl-p-phenylenediamine which was then activated to a mutagen.
208 citations
Journal Article•
TL;DR: A case where repeated occult exposures to tartrazine yellow dye in a patient who could take aspirin with impunity was uncovered by a deduction.
Abstract: Tartrazine dye has been implicated in a variety of adverse reactions. There is a high correlation between aspirin sensitivity and tartrazine sensitivity but the reverse is exceedingly rare. Herewith is presented a case where repeated occult exposures to tartrazine yellow dye in a patient who could take aspirin with impunity was uncovered by a deduction. The ubiquitous nature and protean manifestations of dye sensitivity are discussed.
24 citations
TL;DR: High Performance Liquid Chromatography has been applied to the characterization and quantitation of tartrazine (FD&C Yellow 5) in a variety of food products and recovery studies of 93–97% indicate method accuracy from three food matrices.
Abstract: High Performance Liquid Chromatography (HPLC) has been applied to the characterization and quantitation of tartrazine (FD&C Yellow 5) in a variety of food products. After extraction, HPLC analysis is complete within 10 min. Recovery studies of 93–97% indicate method accuracy from three food matrices. The method exhibits a %Cv of less than 5% for standards and samples. This method also separates Yellow 5 from Red 2, and Red 40.
20 citations
Patent•
03 Jun 1981
TL;DR: A toxicity depressant against an edible azo dye comprising chlorella powder (it is not necessarily a specific one but one prepared conventionally) as an active ingredient is proposed in this paper.
Abstract: PURPOSE:To toxicity depressant against an edible azo dye preventing an increase in weight of body, having toxicity, eg, carcinogenicity, etc, comprising chlorella powder as an active ingredient CONSTITUTION:A toxicity depressant against an edible azo dye comprising chlorella powder (it is not necessarily a specific one but one prepared conventionally) as an active ingredient An edible azo dye, eg, Amaranth shown by the formula I, new coccine shown by the formula II, tartrazine, sunset yellow FCF, etc is used for various kinds of foods, drugs, cosmetics, etc, but it prevents an increase in weight and has side effects, eg, carcinogenicity, etc The test of rats has shown that the use of the azo dye together with chlorella powder can almost prevent the suppression of increase in weight of body and various organs
1 citations