Showing papers on "Tumour heterogeneity published in 1985"

Monoclonal antibody therapy of lymphoid malignancy.

Abstract: Monoclonal antibodies which bind to tumour cell surface antigens have produced regressions of malignancies in an increasing number of clinical trials. The largest experience to date is in the treatment of refractory B and T lymphoid tumours using a variety of intravenously administered mouse monoclonal antibodies. Treatment with antibodies against common differentiation antigens or very specific anti-idiotype antibodies has been effective in both cases. Toxicity has been acceptably low. A number of problems which limit the application and efficacy of monoclonal antibody therapy of lymphoid malignancy have been identified. Most prominent among these are tumour heterogeneity, which allows non-antibody binding subpopulations of the tumour to escape therapy, and the patient's immunological response to the monoclonal antibody-tumour cell complex. As more experience is accumulated, solutions to these problems will be found.

The subrenal capsule assay (SRCA) and its predictive value in oncology.

Abstract: This report has been prepared as a mini-review of the studies and data, accumulated by a number of investigators since 1978, that are relevant to the 6-day subrenal capsule assay (SRCA) as a predictive in vivo test system. Stressing the need to maintain simplicity and economy, the data reviewed are based on the use of normal, immunocompetent mice and a simple tumour size parameter for evaluating drug activity within a 6-day time frame. Both the laboratory and clinical data that are presented and evaluated support the 6-day SRCA as a predictive test system at the preclinical and clinical levels of drug development and treatment. The question, do host responses create an artifact in the tumour size parameter, is addressed with experimental data illustrating the sensitivity of tumour xenografts, prepared from endocrine target tissues, to respond to biological effects in the 6-day SRCA. SRCA data are also presented suggesting that tumour heterogeneity does not automatically preclude the usefulness of predictive assays based upon a tumour sample.

Clonal heterogeneity in a case of Merkel cell carcinoma demonstrated by flow cytometry.

Abstract: A 66-year-old female patient is presented in whom a rapidly growing tumour developed on the glabella. Light and electron microscopy confirmed Merkel cell carcinoma. Flow cytometry (FCM), performed of a tumour specimen, yielded multiple aneuploid stem lines. The FCM data are discussed with regard to the histological features and the biological behaviour of the tumour.