Showing papers on "Undifferentiated connective tissue disease published in 1990"
TL;DR: The facial numbness was frequently associated with moderate to severe facial pain that was usually resistant to pharmacologie therapy, and none of the patients developed clinical or laboratory evidence of systemic vasculitis.
Abstract: We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associated CTDs were undifferentiated connective tissue disease (38/81, 47%), mixed connective tissue disease (21/81, 26%), and scleroderma (15/81, 19%). Of 66 patients followed for more than 1 year (median, 5 years; range, 1 to 26 years), 8/66 patients (12%) had mild improvement and 2/66 (3%) had marked improvement of numbness; no patient had complete return of sensation. The facial numbness was frequently associated with moderate to severe facial pain that was usually resistant to pharmacologic therapy. None of the patients developed clinical or laboratory evidence of systemic vasculitis. The etiology of this cranial sensory neuropathy remains obscure.
85 citations
TL;DR: Early pulmonary involvement in Scl syndromes is functionally characterized by a lowered Dm, correlating with morphologic changes of the nailfold capillaries, probably a reflection of RP of the pulmonary vasculature.
27 citations
TL;DR: The authors conclude that the presence of digital cyanosis is indicative of connective tissue disease and related to evidence of impaired digital venous capacitance, which may underlie the frequent presence of edema in these patients and may be implicated in the pathogenesis of capillary loop abnormalities.
Abstract: Matched groups of 7 to 8 patients with primary Raynaud's phenomenon, systemic sclerosis, and undifferentiated connective tissue disease and cold tolerant normal control subjects were studied by simultaneous digital strain gauge plethysmography and laser Doppler capillary velocimetry during two controlled cycles of hand warming and cooling. Nailfold capillaroscopic assessments and measures of in vivo platelet activation were performed. Triphasic color changes were present in all patients with systemic sclerosis, in 6 of 8 with undifferentiated connective tissue disease, but in only 1 of 7 with primary Raynaud's phenomenon. The occurrence of cyanosis correlated with evidence of impaired venous volume by strain gauge plethysmography and with higher degrees of capillary loop architectural abnormalities. The authors conclude that the presence of digital cyanosis is indicative of connective tissue disease and related to evidence of impaired digital venous capacitance. This may underlie the frequent presence of edema in these patients and may be implicated in the pathogenesis of capillary loop abnormalities.
5 citations
TL;DR: A patient with a two-year history of undifferentiated connective tissue disease had corneal thinning as the sole manifestation of its recurrence and systemic immunosuppressive therapy was not indicated in view of the localized ocular disease.
Abstract: A patient with a two-year history of undifferentiated connective tissue disease had corneal thinning as the sole manifestation of its recurrence. Systemic immunosuppressive therapy was not indicated in view of the localized ocular disease. The patient was treated with tarsorrhaphy and ocular lubricants. One year later, when two new areas of localized thinning were found, a conjunctival wedge resection was done.
3 citations