A. A. Borodinova

TL;DR: General and specific transcriptomic programs of lifespan extension in mice are described and tools to discover new interventions are provided, including an app that visualizes associations between gene expression changes and longevity.

TL;DR: This review considers the key points in BDNF expression and its proteolysis to BDNF, as well as the role of brain-derived neurotrophic factor in the developing nervous system, in the processes of long-term synaptic plasticity, memory consolidation and extinction, and possible involvement in the development of various nervous system pathologies.

TL;DR: Mechanisms of transcriptional and translational control of atypical protein kinases and their roles in induction and maintenance of long-term synaptic plasticity and memory in vertebrates and invertebrates are considered.

TL;DR: It can be assumed that the reversible post-translational histone modifications serve as the basis of plastic changes in the neural network, and DNA methylation and methylation-dependent 3D chromatin organization can serve a stable molecular basis for long-term maintenance of plasticChanges and memory.

TL;DR: Genes, encoding memory-related aPKC, may represent the molecular targets for epigenetic regulation through posttranslational histone modifications, and it was shown that epigenetically-triggered differential expression of PKMζ and PKCζ mRNA depended on protein synthesis.