P
Philipp Khaitovich
Researcher at Skolkovo Institute of Science and Technology
Publications - 141
Citations - 12593
Philipp Khaitovich is an academic researcher from Skolkovo Institute of Science and Technology. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 51, co-authored 135 publications receiving 11023 citations. Previous affiliations of Philipp Khaitovich include University of Illinois at Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
The evolution of gene expression levels in mammalian organs
David Brawand,Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Philippe Julien,Philippe Julien,Gábor Csárdi,Gábor Csárdi,Patrick Harrigan,Manuela Weier,Angélica Liechti,Ayinuer Aximu-Petri,Martin Kircher,Frank W. Albert,Ulrich Zeller,Philipp Khaitovich,Frank Grützner,Sven Bergmann,Sven Bergmann,Rasmus Nielsen,Rasmus Nielsen,Svante Pääbo,Henrik Kaessmann +23 more
TL;DR: It is shown that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation.
Journal ArticleDOI
Intra- and interspecific variation in primate gene expression patterns
Wolfgang Enard,Philipp Khaitovich,Joachim Klose,Sebastian Zöllner,Florian Heissig,Patrick Giavalisco,Kay Nieselt-Struwe,Elaine A. Muchmore,Elaine A. Muchmore,Ajit Varki,Rivka Ravid,Gaby G. M. Doxiadis,Ronald E. Bontrop,Svante Pääbo +13 more
TL;DR: Three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans are studied, and species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain are identified.
Journal ArticleDOI
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
Philipp Khaitovich,Ines Hellmann,Wolfgang Enard,Katja Nowick,Marcus Leinweber,Marcus Leinweber,Henriette Franz,Gunter Weiss,Michael Lachmann,Svante Pääbo +9 more
TL;DR: It is found that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage, and patterns suggestive of positive selection on sequence changes as well as expression changes are seen.
Journal ArticleDOI
Fast Mapping of Short Sequences with Mismatches, Insertions and Deletions Using Index Structures
Steve Hoffmann,Christian Otto,Stefan Kurtz,Cynthia M. Sharma,Philipp Khaitovich,Jörg Vogel,Peter F. Stadler,Jörg Hackermüller +7 more
TL;DR: A matching model for short reads that can handle the problem of leading and trailing contaminations caused by primers and poly-A tails in transcriptomics or the length-dependent increase of error rates is introduced and shows significantly increased performance.
Journal ArticleDOI
Organoid single-cell genomic atlas uncovers human-specific features of brain development
Sabina Kanton,Michael Boyle,Zhisong He,Zhisong He,Malgorzata Santel,Anne Weigert,Fátima Sanchís-Calleja,Fátima Sanchís-Calleja,Patricia Guijarro,Leila Sidow,Jonas Simon Fleck,Dingding Han,Zhengzong Qian,Michael Heide,Wieland B. Huttner,Philipp Khaitovich,Philipp Khaitovich,Philipp Khaitovich,Svante Pääbo,Barbara Treutlein,Barbara Treutlein,J. Gray Camp +21 more
TL;DR: The data provide a temporal cell atlas of great ape forebrain development, and illuminate dynamic gene-regulatory features that are unique to humans, using single-cell transcriptomics and accessible chromatin profiling in stem cell-derived cerebral organoids to investigate gene-Regulatory changes that are specific to humans.