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A. A. L. Gunatilaka
Researcher at Virginia Tech
Publications - 27
Citations - 718
A. A. L. Gunatilaka is an academic researcher from Virginia Tech. The author has contributed to research in topics: Sesquiterpene & Cytotoxicity. The author has an hindex of 14, co-authored 27 publications receiving 678 citations.
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Journal ArticleDOI
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea
TL;DR: The oxoaporphine alkaloids oxophoebine and liriodenine have been isolated from Xylopia aethiopica and showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae.
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Biological activity of some coumarins from Sri Lankan Rutaceae.
A. A. L. Gunatilaka,David G. I. Kingston,Wijeratne Em,B. M. R. Bandara,Glenn A. Hofmann,Randall K. Johnson +5 more
TL;DR: Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts and seselin and xanthyletin were found to be active.
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Synthesis and Biological Evaluation of 2-Acyl Analogues of Paclitaxel (Taxol)
David G. I. Kingston,Ashok G. Chaudhary,Mahendra D. Chordia,Milind M. Gharpure,A. A. L. Gunatilaka,P. I. Higgs,John M. Rimoldi,L. Samala,Prakash Jagtap,Paraskevi Giannakakou,Y. Q. Jiang,Chii M. Lin,Ernest Hamel,Byron H. Long,Craig R. Fairchild,Kathy A. Johnston +15 more
TL;DR: Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement, and the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.
Journal ArticleDOI
Bioactive and other sesquiterpenoids from Porella cordeana
G. G. Harrigan,Ahmad Bayiz Ahmad,Nina J. Baj,Thomas E. Glass,A. A. L. Gunatilaka,David G. I. Kingston +5 more
TL;DR: Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin and aristolone, which were moderately toxic towards DNA-repair-deficient mutants of Saccharomyces cerevisiae.
Journal ArticleDOI
Isolation, synthesis, and structure-activity relationships of bioactive benzoquinones from Miconia lepidota from the Suriname rainforest.
A. A. L. Gunatilaka,John M. Berger,Randy Evans,James S. Miller,Jan H. Wisse,Kim Neddermann,Isia Bursuker,David G. I. Kingston +7 more
TL;DR: Bioactivity-directed fractionation of an EtOAc extract from the leaves of Miconia lepidota afforded the two benzoquinones 1 and 2 exhibited activity toward mutant yeast strains based on Saccharomyces cerevisiae, indicative of their cytotoxicity and potential anticancer activity.