A
A Ayres
Researcher at St. Vincent's Health System
Publications - 5
Citations - 661
A Ayres is an academic researcher from St. Vincent's Health System. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 4, co-authored 5 publications receiving 643 citations.
Papers
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Journal ArticleDOI
Clinical Emergence of Entecavir-Resistant Hepatitis B Virus Requires Additional Substitutions in Virus Already Resistant to Lamivudine
Daniel J. Tenney,Steven Levine,Ronald E. Rose,Ann W. Walsh,S P Weinheimer,Linda Discotto,Mary Jane Plym,Kevin A. Pokornowski,Cheng-Fang Yu,Peter W Angus,A Ayres,Angeline Bartholomeusz,William Sievert,Geoff Thompson,Nadia Warner,Stephen Locarnini,Richard J. Colonno +16 more
TL;DR: Infrequent ETV resistance can emerge during prolonged therapy, with selection of additional RT substitutions within a 3TCr HBV background, leading to reduced ETV susceptibility and treatment failure.
Journal ArticleDOI
Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: lack of potency and selection of resistance mutations.
A Ayres,Lilly Yuen,Kathy Jackson,S. Manoharan,A. Glass,Maria Maley,W. Yoo,Seung Pyo Hong,Sangcheol Kim,Fabio Luciani,D. S. Bowden,Julianne Bayliss,Miriam T. Levy,Stephen Locarnini +13 more
TL;DR: UDPS showed that LMV therapy resulted in increased viral quasispecies diversity and positive selection of HBV variants with reverse transcriptase amino acid substitutions at sites associated with primary LMV resistance in four women, and drug‐resistant viral variants emerged.
Journal ArticleDOI
Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease.
Hossein Poustchi,Hossein Poustchi,Ashraf Mohamadkhani,Scott Bowden,Ghodratollah Montazeri,A Ayres,Peter Revill,Geoffrey C. Farrell,Stephen Locarnini,Jacob George,Reza Malekzadeh +10 more
TL;DR: The results indicate that in genotype D CHB, the presence of the A1762T‐G1764A mutation was associated with more aggressive liver disease while the G1757A substitution wasassociated with protection from advanced disease.
Patent
Hbv variants detection and application
Angeline Ingrid Bartholomeusz,Stephen Locarnini,A Ayres,Lilly Ka Wai Yuen,Joseph John Sasadeusz +4 more
TL;DR: In this article, the hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.
Patent
Viral variants detection and application
Angeline Ingrid Bartholomeusz,Stephen Locarnini,A Ayres,Lilly Ka Wai Yuen,Joseph John Sasadeusz +4 more
TL;DR: In this paper, the hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.