A
A. García-Curiel
Researcher at University of Seville
Publications - 12
Citations - 622
A. García-Curiel is an academic researcher from University of Seville. The author has contributed to research in topics: Acinetobacter baumannii & Imipenem. The author has an hindex of 10, co-authored 12 publications receiving 593 citations. Previous affiliations of A. García-Curiel include Carlos III Health Institute.
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Journal ArticleDOI
Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii
María Eugenia Pachón-Ibáñez,Fernando Docobo-Pérez,Rafael López-Rojas,Juan Domínguez-Herrera,Manuel E. Jiménez-Mejías,A. García-Curiel,C. Pichardo,Luis Jiménez,Jerónimo Pachón +8 more
TL;DR: Rifampin in monotherapy or with imipenem, sulbactam, or colistin showed efficacy against MDR A. baumannii in experimental models of pneumonia and meningitis.
Journal ArticleDOI
Reliability of the E-Test Method for Detection of Colistin Resistance in Clinical Isolates of Acinetobacter baumannii
Luis A. Arroyo,A. García-Curiel,María Eugenia Pachón-Ibáñez,Ana C. Llanos,Maite Ruiz,Jerónimo Pachón,Javier Aznar +6 more
TL;DR: The E-test to the broth microdilution method for testing the susceptibility of 115 clinical isolates of Acinetobacter baumannii to colistin found poor concordance, particularly in extreme dilutions with higher MICs by the E- test method.
Journal ArticleDOI
Imipenem, doxycycline and amikacin in monotherapy and in combination in Acinetobacter baumannii experimental pneumonia.
M.J. Rodríguez-Hernández,Jerónimo Pachón,C. Pichardo,L. Cuberos,José Ibáñez-Martínez,A. García-Curiel,F. J. Caballero,Ignacio Moreno,Manuel E. Jiménez-Mejías +8 more
TL;DR: Doxycycline plus amikacin is an alternative to imipenem in the therapy of A. baumannii pneumonia and the addition of amkacin does not improve the results obtained by imipanem monotherapy.
Journal ArticleDOI
Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains
María-Jesús Rodríguez-Hernández,L. Cuberos,C. Pichardo,F. J. Caballero,Ignacio Moreno,M. Enrique Jiménez-Mejías,A. García-Curiel,Jerónimo Pachón +7 more
TL;DR: The results show the efficacy of sulbactam in infections caused by susceptible strains of A. baumannii, with an MIC up to 4 mg/L, provided that doses reach a t > MIC similar to that of imipenem.
Journal ArticleDOI
Pharmacokinetic ⁄pharmacodynamic assessment of the in-vivo efficacy of imipenem alone or in combination with amikacin for the treatment of experimental multiresistant Acinetobacter baumannii pneumonia
Máximo Bernabeu-Wittel,C. Pichardo,A. García-Curiel,María Eugenia Pachón-Ibáñez,J. Ibáñez-Martínez,Manuel E. Jiménez-Mejías,Jerónimo Pachón +6 more
TL;DR: Combined use of imipenem with amikacin was less efficacious than monotherapy, probably because of a drug-drug interaction that resulted in decreased pharmacokinetic and pharmacodynamic parameters for both antimicrobial agents.