C
C. Pichardo
Researcher at University of Seville
Publications - 19
Citations - 833
C. Pichardo is an academic researcher from University of Seville. The author has contributed to research in topics: Imipenem & Acinetobacter baumannii. The author has an hindex of 14, co-authored 19 publications receiving 802 citations. Previous affiliations of C. Pichardo include Carlos III Health Institute & Spanish National Research Council.
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Journal ArticleDOI
Activity of Tigecycline (GAR-936) against Acinetobacter baumannii Strains, Including Those Resistant to Imipenem
María Eugenia Pachón-Ibáñez,Manuel E. Jiménez-Mejías,C. Pichardo,Ana Cristina Llanos,Jerónimo Pachón +4 more
TL;DR: These in vitro results show that tigecycline has good in vitro bacteriostatic activity against A. baumannii, including strains resistant to imipenem.
Journal ArticleDOI
Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii
María Eugenia Pachón-Ibáñez,Fernando Docobo-Pérez,Rafael López-Rojas,Juan Domínguez-Herrera,Manuel E. Jiménez-Mejías,A. García-Curiel,C. Pichardo,Luis Jiménez,Jerónimo Pachón +8 more
TL;DR: Rifampin in monotherapy or with imipenem, sulbactam, or colistin showed efficacy against MDR A. baumannii in experimental models of pneumonia and meningitis.
Journal ArticleDOI
Imipenem, doxycycline and amikacin in monotherapy and in combination in Acinetobacter baumannii experimental pneumonia.
M.J. Rodríguez-Hernández,Jerónimo Pachón,C. Pichardo,L. Cuberos,José Ibáñez-Martínez,A. García-Curiel,F. J. Caballero,Ignacio Moreno,Manuel E. Jiménez-Mejías +8 more
TL;DR: Doxycycline plus amikacin is an alternative to imipenem in the therapy of A. baumannii pneumonia and the addition of amkacin does not improve the results obtained by imipanem monotherapy.
Journal ArticleDOI
Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains
María-Jesús Rodríguez-Hernández,L. Cuberos,C. Pichardo,F. J. Caballero,Ignacio Moreno,M. Enrique Jiménez-Mejías,A. García-Curiel,Jerónimo Pachón +7 more
TL;DR: The results show the efficacy of sulbactam in infections caused by susceptible strains of A. baumannii, with an MIC up to 4 mg/L, provided that doses reach a t > MIC similar to that of imipenem.
Journal ArticleDOI
Pharmacokinetic ⁄pharmacodynamic assessment of the in-vivo efficacy of imipenem alone or in combination with amikacin for the treatment of experimental multiresistant Acinetobacter baumannii pneumonia
Máximo Bernabeu-Wittel,C. Pichardo,A. García-Curiel,María Eugenia Pachón-Ibáñez,J. Ibáñez-Martínez,Manuel E. Jiménez-Mejías,Jerónimo Pachón +6 more
TL;DR: Combined use of imipenem with amikacin was less efficacious than monotherapy, probably because of a drug-drug interaction that resulted in decreased pharmacokinetic and pharmacodynamic parameters for both antimicrobial agents.