Glycidol represents a latent cyclic AB2-type monomer that can be polymerized in a ring-opening multibranching polymerization (ROMBP). Hyperbranched aliphatic polyethers with controlled molecular weights and narrow molecular weight distribution have been prepared via anionic polymerization of glycidol with rapid cation-exchange equilibrium. 1,1,1-Tris(hydroxymethyl)propane (TMP) was partially deprotonated (10%) and used as initiator for the anionic polymerization carried out under slow addition conditions to minimize polymerization without initiator as well as cyclization. 13C NMR spectra were employed to assess the degree of branching (DB), which was in the range 0.53−0.59. 13C NMR, MALDI-TOF mass spectrometry, vapor pressure osmometry (VPO), and GPC were used to characterize molecular weights and polydispersities of the polyols formed, showing good agreement. n for the polymers prepared was in the range 15−83 (Mn = 1250−6500), and Mw/Mn obtained was 1.13−1.47, being exceptionally low for hyperbranched...

Controlled Synthesis of Hyperbranched Polyglycerols by Ring-Opening Multibranching Polymerization

The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

Dendritic polyglycerols for biomedical applications.

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

and Technologies Marc Sutter,† Eric Da Silva,† Nicolas Duguet,† Yann Raoul,‡ Estelle Met́ay,† and Marc Lemaire*,† †Equipe Catalyse Synthes̀e Environnement, Institut de Chimie et Biochimie Molećulaires et Supramolećulaires, UMR-CNRS 5246, Universite ́ de Lyon, Universite ́Claude Bernard-Lyon 1, Bat̂iment Curien, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France ‡Organisation Nationale Interprofessionnelle des Oleágineux, 11 rue de Monceau, CS 60003, 75378 Paris Cedex 08, France

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A. Haouet

Papers

Preparation et proprietes des poly(R)-glycidols