A. J. MacRobert

TL;DR: Photodynamic therapy with systemically administered ALA may be a promising technique for the treatment of small tumours and areas of dysplasia such as in Barrett's oesophagus.

TL;DR: The results of this study show that toluidine blue-mediated lethal photosensitization of P. gingivalis is possible in vivo and that this results in decreased bone loss, suggesting that photodynamic therapy may be useful as an alternative approach for the antimicrobial treatment of periodontitis.

TL;DR: This is the first report of tumour necrosis brought about by photodynamic activation of a temporary endogenous porphyrin accumulation, after an oral dose of the haem precursor, 5-aminolaevulinic acid.

TL;DR: ALA may be superior to conventional sensitiser for tumours that produce haem as the PP IX is synthesised in malignant cells while the other sensitisers mainly localise to the vascular stroma of tumours, raising the possibility of more selective necrosis in tumours.

TL;DR: The porphyrin sensitisation kinetics profile in the stomach, colon and bladder in normal rats following enterally and parenterally administered ALA was studied using microscopic fluorescence photometric studies of frozen tissue sections and the highest level of fluorescence was achieved in the gastric mucosa and in decreasing levels, colonic and bladder mucosa.