Effects of pesticidal stress amongst pesticide factory workers in Agra, India

Pyrethrins and pyrethrum are the most frequently used home and garden insecticides in the India. They are often used in indoor sprays, pet shampoos, and aerosol bombs to kill flying and jumping insects. Pyrethrins are a common cause of insecticide poisonings. According to Ministry of Environment and Forest survey of poison control centers, they cause more insecticide poisoning incidents than any other class of insecticides except the organophosphates. Symptoms include headaches, dizziness, and difficulty breathing. Pyrethrins can trigger life-threatening allergic responses including heart failure and severe asthma. In laboratory animals exposed through eating, by injection, or through breathing, pyrethrins have caused anemia. Experiments with dairy cows suggest that nursing mothers exposed to pyrethrins can pass them on to their children. Pyrethrins disrupt the normal functioning of sex hormones. They inhibit binding of sex hormones to human genital skin and proteins in human blood. Pyrethrins are classified as “likely to be human carcinogens” by Environmental Protection Agency (EPA) because they cause thyroid tumors in laboratory tests. Farmers who use pyrethrins have an increased risk of developing leukemia. Pyrethrins are extremely toxic to bees, fish, and other aquatic animals. Following indoor treatments, pyrethrins have persisted up to 2 1/2 months in carpet dust.

https://www.pharmatutor.org/pdf_download/pdf/Vol.%202,%20Issue%206,%20June%202014,%20PharmaTutor,%20Paper-5.pdf

Use of Pyrethrin/ Pyrethrum and its Effect on Environment and Human: A Review

The effect of 25, 50 and 75 mg/kg body wt. chlordane on the blood glucose level and of glucose administration in chlordane intoxicated Indian desert gerbils are investigated. Chlordane produces hyperglycemia and lowers the glucose tolerance indicating an impairment in the uptake and utilization of glucose in intoxicated gerbils. The possible reasons for these effects are discussed.

On effect of chlordane on the blood glucose and of glucose administration on the acute chlordane toxicity in Meriones hurrianae Jerdon, the indian desert gerbil.

Pyrethrins are classified as "likely to be human carcinogens" by EPA because they cause thyroid tumors in laboratory tests. Farmers who use pyrethrins have an increased risk of developing leukemia.

The effect of different doses of pyrethrum on the blood glucose level and glucose tolerance in pytethrum-administered gerbils, were investigated. Pyrethrum produces hyperglycemia and lowers the glucose tolerance indicating an impairment in the uptake and utilization of glucose. The possible reasons for these effects are discussed.

Investigation on the acute toxic effect of pyrethrum on the blood glucose and of glucose administration on the acute pyrethrum toxicity in Meriones hurrianae Jerdon (Rodentia).

A K Karel

Papers

Investigation on the acute toxic effect of pyrethrum on the blood glucose and of glucose administration on the acute pyrethrum toxicity in Meriones hurrianae Jerdon (Rodentia).