A
A.M. Scofield
Researcher at University of London
Publications - 18
Citations - 684
A.M. Scofield is an academic researcher from University of London. The author has contributed to research in topics: Castanospermine & Hydroxymethyl. The author has an hindex of 13, co-authored 18 publications receiving 674 citations. Previous affiliations of A.M. Scofield include Royal Botanic Gardens.
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Journal ArticleDOI
α-Homonojirimycin and 2,5-dihydroxymethyl-3,4-dihydroxy-pyrrolidine: Alkaloidal glycosidase inhibitors in the moth Urania fulgens
Geoffrey C. Kite,Jonathan M. Horn,John T. Romeo,Linda E. Fellows,David C. Leest,A.M. Scofield,Neal Griffith Smith +6 more
TL;DR: Adults, pupae and eggs of the neotropical moth, Urania fulgens, contain a-homonojirimycin and 2,5-dihydroxymethyl-3,4-dhydroxypyrrolidine, two of the alkaloidal glycosidase inhibitors that occur in the larval foodplant, Omphalea diandra.
Journal ArticleDOI
Inhibition of thioglucosidase-catalysed glucosinolate hydrolysis by castanospermine and related alkaloids.
A.M. Scofield,John T. Rossiter,Peter Witham,Geoffrey C. Kite,Geoffrey C. Kite,Robert J. Nash,Robert J. Nash,Linda E. Fellows,Linda E. Fellows +8 more
TL;DR: The ability of some naturally occurring polyhydroxyalkaloids to inhibit the hydrolysis of the glucosinolates, sinigrin (allylglucosinolate) and progoitrin, by thioglucosidases from mustard and the cabbage aphid was assessed.
Journal ArticleDOI
Castanospermine and other polyhydroxy alkaloids as inhibitors of insect glycosidases
TL;DR: The identification of an isomaltase in the Tenebrionidae illustrates the value of the alkaloids as taxonomic tools.
Book ChapterDOI
Castanospermine, Swainsonine and Related Polyhydroxy Alkaloids: Structure, Distribution and Biological Activity
TL;DR: Alkaloids which are inhibitors of glycosidases are now believed to be widespread in plants and microorganisms, providing molecular biologists with tools with which to probe many hitherto intractable problems of molecular biology, including cancer metastasis, viral infectivity and the immune response.
Journal ArticleDOI
Alkaloidal glycosidase inhibitors and digestive glycosidase inhibition in specialist and generalist herbivores of Omphalea diandra
TL;DR: U. fulgens does appear to be unique among Omphalea-feeding insects in its ability to accumulate AGIs, suggesting that it gains some advantage from storing these compounds.