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A. Nesterovitch
Researcher at University of Illinois at Chicago
Publications - 7
Citations - 116
A. Nesterovitch is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Epitope & Angiotensin-converting enzyme. The author has an hindex of 3, co-authored 7 publications receiving 104 citations. Previous affiliations of A. Nesterovitch include Rush University Medical Center.
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Journal ArticleDOI
Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action.
O. E. Skirgello,Irina V. Balyasnikova,P.V. Binevski,Zhu Li Sun,Igor I. Baskin,Vladimir A. Palyulin,A. Nesterovitch,Ronald F. Albrecht,Olga A. Kost,Sergei M. Danilov +9 more
TL;DR: Kinetic analysis indicates that both mAbs bind better with the ACE N-domain in the presence of a substrate, which, in turn, implies that binding of a substrates causes conformational adjustments in the N- domain structure.
Journal ArticleDOI
Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding.
Kerry Gordon,Irina V. Balyasnikova,A. Nesterovitch,D. E. Schwartz,Edward D. Sturrock,Sergei M. Danilov +5 more
TL;DR: Two mAbs are characterized, 9B9 and 3G8, that recognize the N domain of ACE and that influence shedding and dimerization and three mutations within the overlapping region of these two epitopes, Q18H, L19E, and Q22A were introduced into full-length somatic ACE to determine their influence on ACE expression and processing.
Journal ArticleDOI
Monoclonal Antibodies 1G12 and 6A12 to the N-domain of human angiotensin-converting enzyme: fine epitope mapping and antibody-based detection of ACE inhibitors in human blood.
Irina V. Balyasnikova,O. E. Skirgello,P.V. Binevski,A. Nesterovitch,Ronald F. Albrecht,Olga A. Kost,Sergei M. Danilov +6 more
TL;DR: It is demonstrated a possibility to employ these mAbs (1G12 or 6A12) for detection and quantification of the presence of ACE inhibitors in human blood and this method should find wide application in monitoring clinical trials with ACE inhibitors as well as in the development of the approach for personalized medicine by these effective drugs.
Journal Article
Angiotensin I-converting enzyme mutation (Y465D) cause dramatic increase in blood ACE via accelerated ACE shedding due to changes of ACE dimerization
Sergei M. Danilov,Kerry Gordon,A. Nesterovitch,H. Luensdorf,Zhenlong Chen,Maricela Castellon,Isolda A. Popova,Sergey Kalinin,Emma Mendonca,Pavel A. Petukhov,David E. Schwartz,Richard D. Minshall,Edward D. Sturrock +12 more