R
Richard D. Minshall
Researcher at University of Illinois at Chicago
Publications - 213
Citations - 12614
Richard D. Minshall is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Caveolin 1 & Endothelial stem cell. The author has an hindex of 60, co-authored 196 publications receiving 11098 citations. Previous affiliations of Richard D. Minshall include University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Regulation of endothelial junctional permeability.
TL;DR: The endothelium is a semi‐permeable barrier that regulates the flux of liquid and solutes, including plasma proteins, between the blood and surrounding tissue and the mechanisms that regulate paracellular permeability are provided.
Journal ArticleDOI
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Thomas J. Park,Jane Reznick,Bethany L. Peterson,Gregory R.C. Blass,Damir Omerbašić,Nigel C. Bennett,P. Henning J. L. Kuich,Christin Zasada,Brigitte M. Browe,Wiebke Hamann,Daniel T. Applegate,Michael H. Radke,Tetiana Kosten,Heike Lutermann,Victoria M Gavaghan,Ole Eigenbrod,Valérie Bégay,Vince G. Amoroso,Vidya Govind,Richard D. Minshall,Ewan St. John Smith,John Larson,Michael Gotthardt,Stefan Kempa,Gary R. Lewin,Gary R. Lewin +25 more
TL;DR: The metabolic rewiring of glycolysis can circumvent the normally lethal effects of oxygen deprivation, a mechanism that could be harnessed to minimize hypoxic damage in human disease.
Journal ArticleDOI
Vascular dysfunction-The disregarded partner of Alzheimer's disease
Melanie D. Sweeney,Axel Montagne,Abhay P. Sagare,Daniel A. Nation,Lon S. Schneider,Helena C. Chui,Michael G. Harrington,Judy Pa,Meng Law,Danny J.J. Wang,Russell E. Jacobs,Fergus N. Doubal,Joel Ramirez,Sandra E. Black,Helene Benveniste,Martin Dichgans,Costantino Iadecola,Seth Love,Philip M.W. Bath,Philip M.W. Bath,Hugh S. Markus,Rustam Al-Shahi Salman,Stuart M. Allan,Terence J. Quinn,Rajesh N. Kalaria,David J. Werring,Roxana O. Carare,Rhian M. Touyz,Steve C.R. Williams,Michael A. Moskowitz,Zvonimir S. Katusic,Sarah E. Lutz,Orly Lazarov,Richard D. Minshall,Jalees Rehman,Thomas P. Davis,Cheryl L. Wellington,Hector M. González,Chun Yuan,Samuel N. Lockhart,Timothy M. Hughes,Christopher Chen,Perminder S. Sachdev,John T. O'Brien,Ingmar Skoog,Leonardo Pantoni,Deborah Gustafson,Geert Jan Biessels,Anders Wallin,Eric E. Smith,Vincent Mok,Adrian Wong,Peter Passmore,Frederick Barkof,Frederick Barkof,Majon Muller,Monique M.B. Breteler,Monique M.B. Breteler,Gustavo C. Román,Edith Hamel,Sudha Seshadri,Sudha Seshadri,Rebecca F. Gottesman,Mark A. van Buchem,Zoe Arvanitakis,Julie A. Schneider,Lester R. Drewes,Vladimir Hachinski,Caleb E. Finch,Arthur W. Toga,Joanna M. Wardlaw,Berislav V. Zlokovic +71 more
TL;DR: Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize and should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.
Journal ArticleDOI
Caveolin regulation of endothelial function.
TL;DR: Findings from studies examining the functions of caveolin-1, the 22-kDa caveolar protein that oligomerizes and inserts into the cytoplasmic face of the plasma membrane, indicate its importance in cardiac and lung development.
Journal ArticleDOI
Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway
Richard D. Minshall,Chinnaswamy Tiruppathi,Stephen M. Vogel,Walter D. Niles,Annette Gilchrist,Heidi E. Hamm,Asrar B. Malik +6 more
TL;DR: Vesicle formation induced by gp60 and migration of vesicles to the basolateral membrane requires the interaction of gp60 with caveolin-1, followed by the activation of the downstream Gi-coupled Src kinase signaling pathway, indicating the dissociation of hydraulic conductivity from the albumin permeability pathway.