https://www.gastrojournal.org/article/0016-5085(95)90340-2/pdf

Trefoil Peptide Protection of Intestinal Epithelial Barrier Function: Cooperative Interaction With Mucin Glycoprotein

Antinutritional properties of plant lectins

Arcelin, a major seed protein discovered in wild beans ( Phaseolus vulgaris ), has toxic effects on an important bean bruchid pest, Zabrotes subfasciatus. Transfer of the arcelin-1allele to bean cultivars and addition of purified arcelin to artificial seeds results in high levels of insect resistance. The nucleotide and derived amino acid sequences of the arcelin-1 complementary DNA are very similar to those of genes encoding the bean seed lectin, phytohemagglutinin. The gene or genes encoding arcelin may have evolved from a phytohemagglutinin gene or genes resulting in an effective mechanism for resistance to bean bruchids.

http://science.sciencemag.org/content/sci/240/4849/207.full.pdf

Insecticidal activity and lectin homology of arcelin seed protein.

Immunohistochemical and developmental studies to elucidate the mechanism of action of the snowdrop lectin on the rice brown planthopper, Nilaparvata lugens (Stal).

A comprehensive review on the presence of certain important anti-nutritional and toxic factors in food legumes has been conducted. These substances include proteolytic inhibitors, phytohemagglutinins, lathyrogens, cyanogenetic compounds, compounds causing favism, factors affecting digestibility and saponins. These factors are shown to be widely present in leguminous foods which are important constituents of the diet of a large section of the world's population, and particularly, of people in the developing countries.

A. Pusztai

Papers

Kidney bean (Phaseolus vulgaris) lectin-induced lesions in rat small intestine: 1. Light microscope studies

Kidney bean (Phaseolus vulgaris) lectin-induced lesions in rat small intestine. 3. Ultrastructural studies.

Kidney bean (Phaseolus vulgaris) lectin-induced lesions in rat small intestine: 2. Microbiological studies