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A.T Sullivan
Researcher at GlaxoSmithKline
Publications - 3
Citations - 1522
A.T Sullivan is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: QT interval & Sudden death. The author has an hindex of 3, co-authored 3 publications receiving 1449 citations.
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Journal ArticleDOI
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs : Evidence for a provisional safety margin in drug development
William S. Redfern,Leif Carlsson,A.S Davis,W G Lynch,I MacKenzie,S Palethorpe,Peter K. S. Siegl,I. Strang,A.T Sullivan,Rob Wallis,A. J. Camm,Tim Hammond +11 more
TL;DR: The dataset confirms the widely-held belief that most drugs associated with TdP in humans are also associated with hERG K(+) channel block at concentrations close to or superimposed upon the free plasma concentrations found in clinical use.
Journal ArticleDOI
Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey
T.G Hammond,Leif Carlsson,A.S Davis,W.G Lynch,I MacKenzie,W.S Redfern,A.T Sullivan,A. J. Camm +7 more
TL;DR: Current practice in the pharmaceutical industry for assessing the potential for QT interval prolongation by non-cardiovascular medicinal products is assessed, providing a snapshot of the practice prior to any internationally-agreed consensus on the most effective and efficient approaches to minimising the risk.
Journal ArticleDOI
Corrigendum to “Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development” [Cardiovasc. Res. 58 (2003) 32–45]
William S. Redfern,Leif Carlsson,A.S Davis,W G Lynch,I MacKenzie,S Palethorpe,Peter K. S. Siegl,I. Strang,A.T Sullivan,Rob Wallis,A. J. Camm,Tim Hammond +11 more
TL;DR: The following minor errors and potential ambiguities have been brought to the authors' attention since publication of the article and none of these affect the interpretation of the data or overall conclusions.