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A. Tyl Hewitt
Researcher at Johns Hopkins University
Publications - 8
Citations - 240
A. Tyl Hewitt is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Extracellular matrix & Fibronectin. The author has an hindex of 5, co-authored 8 publications receiving 236 citations. Previous affiliations of A. Tyl Hewitt include University of Baltimore.
Papers
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Journal ArticleDOI
Detection of specific extracellular matrix molecules in drusen, Bruch's membrane, and ciliary body.
TL;DR: Indirect immunofluorescence reactions on cryostat sections of drusen-bearing human donor eye tissue showed age-related accumulation of type I collagen and localized changes associated with some Drusen.
Journal ArticleDOI
Absence of normal keratan sulfate in the blood of patients with macular corneal dystrophy.
Eugene J.-M.A. Thonar,Roger F. Meyer,Richard F. Dennis,Mary Ellen Lenz,Brian A. Maldonado,John R. Hassell,A. Tyl Hewitt,Walter J. Stark,E. Lee Stock,Klaus E. Kuettner,Gordon K. Klintworth +10 more
TL;DR: Sulfated keratan sulfate was not detected in the serum of 16 patients with macular corneal dystrophy, but was present at normal levels in 66 patients with other cornea diseases, and this assay should prove useful in the diagnosis of macular Corneal Dystrophy.
Journal ArticleDOI
Detection of extracellular matrix molecules synthesized in vitro by monkey and human retinal pigment epithelium: influence of donor age and multiple passages.
TL;DR: Human and monkey pigment epithelium in vitro should be useful for the study of the synthesis, deposition and supramolecular interactions of a variety of extracellular matrix molecules.
Book ChapterDOI
Attachment Proteins and Their Role in Extracellular Matrices
A. Tyl Hewitt,George R. Martin +1 more
TL;DR: It appears likely that the proteins produced for the matrix of a given tissue show specific interactions that generate a supramolecular complex of defined stoichiometry that determines the physical properties of the tissue but also defines the phenotype of the cells in contact with it.
Journal ArticleDOI
Laminin detection in normal and retinitis pigmentosa human retina.
David A. Newsome,A. Tyl Hewitt +1 more
TL;DR: Quantitation of laminin by ELISA revealed a six- to ten-fold increase in retinitis pigmentosa retinas, as compared with normal, and both glial and retinal pigmented epithelial cells may participate in the gliosis that occurs during the course of retinopathy pigmentosa.