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Aaron L. Magno
Researcher at Lions Eye Institute
Publications - 23
Citations - 1014
Aaron L. Magno is an academic researcher from Lions Eye Institute. The author has contributed to research in topics: Calcium-sensing receptor & Ranibizumab. The author has an hindex of 13, co-authored 23 publications receiving 881 citations. Previous affiliations of Aaron L. Magno include Diabetes Australia & University of Western Australia.
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Journal ArticleDOI
The Calcium-Sensing Receptor: A Molecular Perspective
TL;DR: This review will provide a comprehensive exploration of the different aspects of the receptor, including its structure, stimuli, signalling, interacting protein partners, and tissue expression patterns, and will relate their impact on the functionality of the CaR from a molecular perspective.
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Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial
Elizabeth Rakoczy,Elizabeth Rakoczy,Chooi May Lai,Chooi May Lai,Aaron L. Magno,Matthew E. Wikstrom,Matthew E. Wikstrom,Martyn A. French,Cora M. Pierce,Steven D. Schwartz,Mark S. Blumenkranz,Thomas W. Chalberg,Mariapia A. Degli-Esposti,Mariapia A. Degli-Esposti,Ian J. Constable,Ian J. Constable,Ian J. Constable +16 more
TL;DR: The results support ocular gene therapy as a potential long-term treatment option for wet age-related macular degeneration with a single subretinal injection of rAAV.sFLT-1 was safe and well tolerated and highly reproducible.
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Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration
Ian J. Constable,Ian J. Constable,Ian J. Constable,Cora M. Pierce,Chooi May Lai,Chooi May Lai,Aaron L. Magno,Mariapia A. Degli-Esposti,Mariapia A. Degli-Esposti,Martyn A. French,Ian L. McAllister,Ian L. McAllister,Ian L. McAllister,Steve Butler,Samuel B. Barone,Steven D. Schwartz,Mark S. Blumenkranz,Elizabeth Rakoczy,Elizabeth Rakoczy +18 more
TL;DR: Subretinal rAAV.sFLT-1 combined with the option for co-treatment appears to be a safe and promising approach to the treatment of wAMD.
Journal ArticleDOI
The role of the calcium-sensing receptor in human disease
Bryan K. Ward,Bryan K. Ward,Aaron L. Magno,Aaron L. Magno,John P. Walsh,John P. Walsh,Thomas Ratajczak,Thomas Ratajczak +7 more
TL;DR: Current knowledge of the role of the CaSR in disorders of calcium homeostasis and the use or potential use of CaSR agonists or antagonists and other drugs mediated through the receptor are examined, in the management of disorders as diverse as hyperparathyroidism, osteoporosis and gastrointestinal disease.
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Sequestosome 1 Mutations in Paget's Disease of Bone in Australia: Prevalence, Genotype/Phenotype Correlation, and a Novel Non‐UBA Domain Mutation (P364S) Associated With Increased NF‐κB Signaling Without Loss of Ubiquitin Binding
Sarah L. Rea,Sarah L. Rea,John P. Walsh,L.C. Ward,Aaron L. Magno,Aaron L. Magno,Bryan K. Ward,Bryan K. Ward,Barry Shaw,Robert Layfield,G. Neil Kent,Jiake Xu,Thomas Ratajczak,Thomas Ratajczak +13 more
TL;DR: Functional studies suggest that increased NF‐κB signaling, but not the impairment of ubiquitin binding, may be essential in the pathogenesis of PDB associated with SQSTM1 mutations.