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Aaron W. Feldman
Researcher at Scripps Research Institute
Publications - 19
Citations - 1038
Aaron W. Feldman is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Base pair & Transfer RNA. The author has an hindex of 12, co-authored 19 publications receiving 816 citations. Previous affiliations of Aaron W. Feldman include Connecticut College.
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Films. the spreading of liquids and the spreading coefficient
Journal ArticleDOI
A semi-synthetic organism that stores and retrieves increased genetic information.
Yorke Zhang,Ptacin Jerod,Emil C. Fischer,Hans R. Aerni,Caffaro Carolina E,Kristine M. San Jose,Aaron W. Feldman,Court R. Turner,Floyd E. Romesberg +8 more
TL;DR: In vivo transcription of DNA containing dNaM and dTPT3 into m RNAs with two different unnatural codons and tRNAs with cognate unnatural anticodons, and their efficient decoding at the ribosome to direct the site-specific incorporation of natural or non-canonical amino acids into superfolder green fluorescent protein are reported.
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A semisynthetic organism engineered for the stable expansion of the genetic alphabet
Yorke Zhang,Brian M. Lamb,Aaron W. Feldman,Zhou Anne Xiaozhou,Thomas Lavergne,Lingjun Li,Floyd E. Romesberg +6 more
TL;DR: The optimized SSO grows robustly, constitutively imports the unnatural triphosphates, and is able to indefinitely retain multiple UBPs in virtually any sequence context, creating a form of life that can stably store genetic information using a six-letter, three-base-pair alphabet.
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Expansion of the Genetic Alphabet: A Chemist's Approach to Synthetic Biology.
TL;DR: The efforts resulted in the identification of a family of UBPs that are well recognized by DNA polymerases when incorporated into DNA and that have been used to create semi-synthetic organisms capable of storing and retrieving increased information.
Journal ArticleDOI
New codons for efficient production of unnatural proteins in a semisynthetic organism
Emil C. Fischer,Koji Hashimoto,Yorke Zhang,Aaron W. Feldman,Dien Vivian T,Rebekah J Karadeema,Ramkrishna Adhikary,Michael P. Ledbetter,Ramanarayanan Krishnamurthy,Floyd E. Romesberg +9 more
TL;DR: Systematic characterization of codons using the unnatural base pair dNaM·dTPT3 leads to the discovery of nine new functional codon–anticodon pairs, three of which are shown to be orthogonally decoded by ribosomes and allow incorporation of up to three noncanonical amino acids in Escherichia coli.