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Abbot F. Clark
Researcher at University of North Texas Health Science Center
Publications - 299
Citations - 15573
Abbot F. Clark is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Trabecular meshwork & Glaucoma. The author has an hindex of 65, co-authored 297 publications receiving 13938 citations. Previous affiliations of Abbot F. Clark include University of Iowa & University of North Texas.
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Journal ArticleDOI
Identification of a Gene That Causes Primary Open Angle Glaucoma
Edwin M. Stone,John H. Fingert,Wallace L.M. Alward,Thai Nguyen,Jon R. Polansky,Sara L.F. Sunden,Darryl Y. Nishimura,Abbot F. Clark,Arne M. Nystuen,Brian E. Nichols,David A. Mackey,Robert Ritch,Jeffrey W. Kalenak,E. Randy Craven,Val C. Sheffield +14 more
TL;DR: A gene encoding a trabecular meshwork protein (TIGR) mapped to the narrowest disease interval by STS content and radiation hybrid mapping and will aid in early diagnosis of glaucoma.
Journal ArticleDOI
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
Gareth R. Howell,Danilo G. Macalinao,Gregory L. Sousa,Michael Walden,Ileana Soto,Stephen C. Kneeland,Jessica M. Barbay,Benjamin L. King,Jeffrey K. Marchant,Matthew A. Hibbs,Beth Stevens,Ben A. Barres,Abbot F. Clark,Richard T. Libby,Simon W. M. John,Simon W. M. John +15 more
TL;DR: Early-stage expression changes included upregulation of both the complement cascade and the endothelin system, and so the therapeutic value of separately inhibiting them was tested and mice with a mutation in complement component 1a were protected from glaucoma.
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Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.
Richard T. Libby,Michael G. Anderson,Iok-Hou Pang,Zachary H. Robinson,Olga V. Savinova,I. Mihai Cosma,Amy Snow,Lawriston A. Wilson,Richard S. Smith,Abbot F. Clark,Simon W. M. John +10 more
TL;DR: The period when mice have elevated intraocular pressure extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice, and optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age.
Journal ArticleDOI
TGFβ2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
Debra L. Fleenor,Allan R. Shepard,Peggy E. Hellberg,Nasreen Jacobson,Iok-Hou Pang,Abbot F. Clark +5 more
TL;DR: Investigation of effects of TGFbeta2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor (PAI)-1 from human TM cell cultures and perfused human ocular anterior segments found modulation of T GFbeta2-induced changes in the ECM may provide a novel and viable approach to the management of glaucoma.
Journal ArticleDOI
Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor
Nasreen Jacobson,Michael P. Andrews,Allan R. Shepard,Darryl Y. Nishimura,Charles Searby,John H. Fingert,Greg Hageman,Robert F. Mullins,Beverly L. Davidson,Young H. Kwon,Wallace L.M. Alward,Edwin M. Stone,Abbot F. Clark,Val C. Sheffield +13 more
TL;DR: These studies suggest that MYOC glaucoma is due either to insufficient levels of secreted myocilin or to compromised TM cell function caused by congestion of the TM secretory pathway.