B
Beth Stevens
Researcher at Broad Institute
Publications - 145
Citations - 29852
Beth Stevens is an academic researcher from Broad Institute. The author has contributed to research in topics: Microglia & Synapse. The author has an hindex of 53, co-authored 123 publications receiving 21959 citations. Previous affiliations of Beth Stevens include Stanford University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow,Kevin A. Guttenplan,Laura E. Clarke,Frederick C. Bennett,Christopher J. Bohlen,Lucas Schirmer,Mariko L. Bennett,Alexandra E. Münch,Won-Suk Chung,Todd C. Peterson,Daniel K. Wilton,Arnaud Frouin,Brooke A. Napier,Nikhil Panicker,Manoj Kumar,Marion S. Buckwalter,David H. Rowitch,Valina L. Dawson,Ted M. Dawson,Beth Stevens,Ben A. Barres +20 more
TL;DR: It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases.
Journal ArticleDOI
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Dorothy P. Schafer,Emily K. Lehrman,Amanda G. Kautzman,Ryuta Koyama,Alan R. Mardinly,Ryo Yamasaki,Richard M. Ransohoff,Michael E. Greenberg,Ben A. Barres,Beth Stevens +9 more
TL;DR: It is shown that microglia engulf presynaptic inputs during peak retinogeniculate pruning and that engulfment is dependent upon neural activity and themicroglia-specific phagocytic signaling pathway, complement receptor 3(CR3)/C3.
Journal ArticleDOI
The classical complement cascade mediates CNS synapse elimination.
Beth Stevens,Nicola J. Allen,Luis E. Vazquez,Gareth R. Howell,Karen S. Christopherson,Navid Nouri,Kristina D. Micheva,Adrienne K. Mehalow,Andrew D. Huberman,Benjamin K. Stafford,Alexander Sher,Alan Litke,John D. Lambris,Stephen J. Smith,Simon W. M. John,Ben A. Barres +15 more
TL;DR: It is shown that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and retina, supporting a model in which unwanted synapses are tagged by complement for elimination and suggesting that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease.
Journal ArticleDOI
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong,Victoria F. Beja-Glasser,Bianca M. Nfonoyim,Arnaud Frouin,Shaomin Li,Saranya Ramakrishnan,Katherine Merry,Qiaoqiao Shi,Arnon Rosenthal,Ben A. Barres,Cynthia A. Lemere,Dennis J. Selkoe,Beth Stevens,Beth Stevens +13 more
TL;DR: In mouse models, the complement-dependent pathway and microglia that prune excess synapses in development are inappropriately activated and mediate synapse loss in AD, which is an early feature of Alzheimer's disease and correlates with cognitive decline.
Journal ArticleDOI
Schizophrenia risk from complex variation of complement component 4
Aswin Sekar,Aswin Sekar,Allison R. Bialas,Heather de Rivera,Heather de Rivera,Avery Davis,Avery Davis,Timothy R. Hammond,Nolan Kamitaki,Nolan Kamitaki,Katherine Tooley,Katherine Tooley,Jessy Presumey,Matthew A. Baum,Vanessa Van Doren,Giulio Genovese,Giulio Genovese,Samuel A. Rose,Robert E. Handsaker,Robert E. Handsaker,Mark J. Daly,Mark J. Daly,Michael C. Carroll,Beth Stevens,Beth Stevens,Steven A. McCarroll,Steven A. McCarroll +26 more
TL;DR: It is found that many structurally diverse alleles of the complement component 4 (C4) genes generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C 4A.