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Abdullah M. Al-Bekairi
Researcher at King Saud University
Publications - 48
Citations - 2219
Abdullah M. Al-Bekairi is an academic researcher from King Saud University. The author has contributed to research in topics: Lipid peroxidation & Toxicity. The author has an hindex of 23, co-authored 47 publications receiving 2094 citations.
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Journal ArticleDOI
Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action
TL;DR: Kinetic parameters for the reduction of T Q to dihydrothymoquinone (DHTQ) indicated that DT‐diaphorase of different tissues can efficiently reduce TQ to DHTQ, and revealed that TQ acted not only as superoxide anion scavengers but also as general free radical scavengers.
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Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism.
Mahmoud N. Nagi,Khurshid Alam,Osama A. Badary,Othman A. Al-Shabanah,H. A. Al-Sawaf,Abdullah M. Al-Bekairi +5 more
TL;DR: Oral administration of TQ in a single dose resulted in significant (p<0.001) protection against the hepatotoxic effects of CCl4.
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Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.
Osama A. Badary,Mahmoud N. Nagi,Othman A. Al-Shabanah,Hussain A Al-Sawaf,Mohammed O Al-Sohaibani,Abdullah M. Al-Bekairi +5 more
TL;DR: TQ-induced amelioration of cisplatin nephrotoxicity was evident by significant reductions in serum urea and creatinine and significant improvement in polyuria, kidney weight, and Creatinine clearance, and the current study suggests that TQ may improve the therapeutic index of cisPlatin.
Journal Article
Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity
Othman A. Al-Shabanah,Osama A. Badary,Mahmoud N. Nagi,N. M. Al-Gharably,Ammar C. Al-Rikabi,Abdullah M. Al-Bekairi +5 more
TL;DR: TQ is supported as a potentially selective cytoprotective agent, which may ameliorate cardiotoxicity without decreasing DOX antitumor activity, and in in vivo study on mouse Ehrlich ascites carcinoma tumor, it could be shown that TQ does not interfere with the antitumors activity of DOX.
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Acute and subchronic toxicity of thymoquinone in mice
Osama A. Badary,Othman A. Al-Shabanah,Mahmoud N. Nagi,Abdullah M. Al-Bekairi,Mohamed M. Elmazar +4 more
TL;DR: The effects of acute and subchronic administration of thymoquinone (TQ), the main constituent of the volatile oil of the black seeds Nigella sativa, with significant cytoprotective properties, were studied in male Swiss albino mice as discussed by the authors.