Showing papers by "Achille P. Caputi published in 1984"
TL;DR: The question whether Nimodipine affects brain functions by other mechanisms than an increase in cerebral blood flow is raised, which appeared to be homogeneous in magnitude and anatomic distribution throughout the brain.
13 citations
Journal Article•
TL;DR: Data strongly support an impairment of cerebral GABA control of blood pressure and heart rate in DOCA-salt hypertensive rats.
Abstract: Cerebral glutamate decarboxylase (GAD) activity in DOCA-salt hypertensive rats showed a significant increase in the mesencephalon and a significant decrease in the cerebral cortex and in the cerebellum, compared to that observed in mononephrectomized normotensive animals. Intracerebroventricular (icv) injection of muscimol (0.5, 1 and 2 micrograms), a GABA receptor agonist, produced a dose-dependent decrease in heart rate (HR), significantly greater in freely moving hypertensive animals than in normotensive controls. Muscimol also reduced mean arterial pressure (MAP). The hypotensive effect induced by muscimol (2 micrograms) was significantly higher in hypertensive animals. Ethanolamine-O-sulphate (5, 10, 20 and 40 microM), an inhibitor of GABA breakdown, determined a decrease in MAP and in HR greater in hypertensive than in normotensive rats. Intraperitoneal injection of valproic acid (50-100 mg/Kg/die) for 6 weeks significantly reduced the development of DOCA-salt hypertension in rats. The anti-hypertensive effect became significant during the 4th week and was dose-dependent. DOCA-salt animals, daily treated with 50 mg/Kg of valproic acid, showed an increased pressor response to intravenous injection of phenylephrine (0.1, 0.5 and 1 microgram/Kg). Data strongly support an impairment of cerebral GABA control of blood pressure and heart rate in DOCA-salt hypertensive rats.
8 citations
TL;DR: Since glucocorticoids feedback regulates biosynthesis and cleavage of pro-opiocortin, nimodipine, which reduces adrenal gland responsiveness to ACTH, might reflexly increase beta-EP release from hypophysis.
7 citations
01 Jan 1984
TL;DR: Endotoxins of Pasteurella multocida, Pseudomonas aeruginosa, Neisseria gonorrhoeae, and Shigella sonnei, when given in a single intravenous injection in the rat, showed antidipsogenic effects on drinking behaviour stimulated by 48 h water deprivation, or by intracerebroventricular injection of carbachol (250 ng).
Abstract: Endotoxins of Pasteurella multocida, Pseudomonas aeruginosa, Neisseria gonorrhoeae, and Shigella sonnei, when given in a single intravenous injection in the rat, showed antidipsogenic effects on drinking behaviour stimulated by 48 h water deprivation, or by intracerebroventricular injection of carbachol (250 ng). In water deprived rats, the antidipsogenic effect was dose related. When drinking was induced by carbachol, endotoxins showed a very long-lasting inhibition. The effect was neither a consequence of behavioural alterations, nor due endotoxin peripheral vasodilatating properties.
2 citations
TL;DR: In conscious rats, a single oral dose of cadmium (Cd) chloride does not alter mean arterial pressure, heart rate and pressor response to phenylephrine 3, 7, and 14 days after loading, but 150 mg/kg of Cd reduce reflex bradycardia and increase centrally mediated vagal decrease in heart rate.
Abstract: In conscious rats, a single oral dose of cadmium (Cd) chloride (up to 150 mg/kg) does not alter mean arterial pressure, heart rate and pressor response to phenylephrine 3, 7, and 14 days after loading. However, 150 mg/kg of Cd reduce reflex bradycardia and increase centrally mediated vagal decrease in heart rate. Therefore, it is suggested that Cd could modify baroreflex control of heart rate through an impairment of the afferent component of the reflex.
2 citations