https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

4.2.8. Reductive Coupling 3109 5. Reaction of Aromatic Compounds 3110 5.1. Electrophilic Substitutions 3110 5.2. Radical Substitution 3111 5.3. Oxidative Coupling 3111 5.4. Photochemical Reactions 3111 6. Reaction of Carbonyl Compounds 3111 6.1. Nucleophilic Additions 3111 6.1.1. Allylation 3111 6.1.2. Propargylation 3120 6.1.3. Benzylation 3121 6.1.4. Arylation/Vinylation 3121 6.1.5. Alkynylation 3121 6.1.6. Alkylation 3121 6.1.7. Reformatsky-Type Reaction 3122 6.1.8. Direct Aldol Reaction 3122 6.1.9. Mukaiyama Aldol Reaction 3124 6.1.10. Hydrogen Cyanide Addition 3125 6.2. Pinacol Coupling 3126 6.3. Wittig Reactions 3126 7. Reaction of R,â-Unsaturated Carbonyl Compounds 3127

Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update

A wide array of forms of palladium has been utilized as precatalysts for Heck and Suzuki coupling reactions over the last 15 years. Historically, nearly every form of palladium used has been described as the active catalytic species. However, recent research has begun to shed light on the in situ transformations that many palladium precatalysts undergo during and before the catalytic reaction, and there are now many suggestions in the literature that narrow the scope of types of palladium that may be considered true “catalysts” in these coupling reactions. In this work, for each type of precatalyst, the recent literature is summarized and the type(s) of palladium that are proposed to be truly active are enumerated. All forms of palladium, including discrete soluble palladium complexes, solid-supported metal ligand complexes, supported palladium nano- and macroparticles, soluble palladium nanoparticles, soluble ligand-free palladium, and palladium-exchanged oxides are considered and reviewed here. A considerable focus is placed on solid precatalysts and on evidence for and against catalysis by solid surfaces vs. soluble species when starting with various precatalysts. The review closes with a critical overview of various control experiments or tests that have been used by authors to assess the homogeneity or heterogeneity of catalyst systems.

On the Nature of the Active Species in Palladium Catalyzed Mizoroki–Heck and Suzuki–Miyaura Couplings – Homogeneous or Heterogeneous Catalysis, A Critical Review

Schiff base ligands are considered “privileged ligands” because they are easily prepared by the condensation between aldehydes and imines. Stereogenic centres or other elements of chirality (planes, axes) can be introduced in the synthetic design. Schiff base ligands are able to coordinate many different metals, and to stabilize them in various oxidation states, enabling the use of Schiff base metal complexes for a large variety of useful catalytic transformations. Practical guidelines for the preparation and use of different Schiff base metal complexes in the field of catalytic transformations are discussed in this tutorial review.

Metal–Salen Schiff base complexes in catalysis: practical aspects

Iron Catalysis in Organic Synthesis

Catalytic asymmetric synthesis of homoallylic alcohols

Mehr als 125 Jahren nach ihrer Entdeckung zahlt die Friedel-Crafts-Alkylierung zu den am besten untersuchten und am haufigsten eingesetzten Reaktionen der organischen Synthese. Worin liegt das Geheimnis dieses erstaunlichen Erfolgs? Vermutlich tragt die Vielseitigkeit dieser Reaktion dazu bei, dass sie auch heute noch entscheidenden Anteil hat an der Synthese immer komplexerer Verbindungen. Es dauerte allerdings mehr als ein Jahrhundert, bis asymmetrische katalytische Varianten fur die Umsetzung einer grosen Bandbreite aromatischer Substrate und Alkylierungsmittel entwickelt wurden. Hier berichten wir uber neueste Entwicklungen und Anwendungen katalytischer stereoselektiver Alkylierungen aromatischer Substrate sowie uber die Synthesen einer grosen Auswahl enantiomerenangereicherter, hoch funktionalisierter Verbindungen.

Neue katalytische Methoden in der stereoselektiven Friedel‐Crafts‐Alkylierung

https://www.rsc.org/suppdata/CC/b6/b613019d/b613019d.pdf

Highly enantioselective nitroaldol reaction catalyzed by new chiral copper complexes

Organometallic ring-opening reactions of N-acyl and N-alkoxycarbonyl lactams. Synthesis of cyclic imines

GENERAL ASPECTS AND HISTORICAL BACKGROUND Introduction General Aspects and Historical Background Catalytic Enantioselective FC Reactions: An Introduction MICHAEL ADDITION Chelating Alpha, Beta-Unsaturated Compounds Simple Alpha, Beta-Unsaturated Substrates Nitroalkenes ADDITION TO CARBONYL COMPOUNDS Aldehydes/Ketones Imines NUCLEOPHILIC ALLYLIC ALKYLATION AND HYDROARYLATION OF ALLENES Introduction Allylic Alkylations Metallo-Catalyzed Hydroarylation of Allenes NUCLEOPHILIC SUBSTITUTION ON CSP3 CARBON ATOMS Ring-Opening of Epoxides Direct Activation of Alcohols UNACTIVATED ALKENES Introduction Early Studies Rh(I)-Catalyzed Enantioselective Hydroarylation of Iminoarenes Pt(II)-Catalyzed Enantioselective Hydroarylation of Alkenylidoles Au(II)-Catalyzed Enantioselective Hydroarylation of Allenylindoles Conclusions and Outlook Experimental: Selected Procedures CATALYTIC ASYMMETRIC FRIEDEL-CRAFTS ALKYLATIONS IN TOTAL SYNTHESIS Introduction Total Synthesis of Indole-Containing Compounds Total Synthesis of Pyrrole-Containing Compounds Friedel-Crafts Alkylation of Furan Derivatives in Total Synthesis Friedel-Crafts Alkylation of Arenes in Total Synthesis Asymmetric Synthesis of Natural Products Based on Diastereoselective Friedel-Crafts Reactions INDUSTRIAL FRIEDEL-CRAFTS IN CHEMISTRY Introduction Green Chemistry and the Friedel-Crafts Reaction Heterogeneous Catalysts for the Friedel-Crafts Reaction Large Scale Hydrocarbon Processing Conclusions and Perspectives

Achille Umani-Ronchi

Papers

Catalytic asymmetric synthesis of homoallylic alcohols

Neue katalytische Methoden in der stereoselektiven Friedel‐Crafts‐Alkylierung

Highly enantioselective nitroaldol reaction catalyzed by new chiral copper complexes

Organometallic ring-opening reactions of N-acyl and N-alkoxycarbonyl lactams. Synthesis of cyclic imines

Catalytic Asymmetric Friedel-Crafts Alkylations