A
Adam Kesingland
Researcher at Novartis
Publications - 8
Citations - 1260
Adam Kesingland is an academic researcher from Novartis. The author has contributed to research in topics: Neuropathic pain & Hyperalgesia. The author has an hindex of 8, co-authored 8 publications receiving 1234 citations.
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Journal ArticleDOI
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
Alyson Fox,Adam Kesingland,Clive Gentry,Kara McNair,Sadhana Patel,Laszlo Urban,Iain F. James +6 more
TL;DR: The data show that cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain and mediated via an action in both the CNS and in the periphery.
Journal ArticleDOI
The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat
Sadhana Patel,Sami Naeem,Adam Kesingland,Wolfgang Froestl,Marco Capogna,Laszlo Urban,Alyson Fox +6 more
TL;DR: Examination of the effects of a novel GABAB agonist in models of chronic neuropathic and inflammatory pain in the rat and its inhibitory action on spinal transmission in vitro indicates that CGP35024 and L‐baclofen modulate nociceptive transmission in the spinal cord to inhibit neuropathic hyperalgesia, and that C GP35024 has a therapeutic window for antihyperalgesIA over spasmolysis.
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Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.
Katharine Walker,M Bowes,Moh Panesar,Andrew J. Davis,Clive Gentry,Adam Kesingland,Fabrizio Gasparini,Will P.J.M Spooren,Natacha Stoehr,Adriana Pagano,Adriana Pagano,Peter J. Flor,Ivo Vranesic,Kurt Lingenhoehl,Edwin C. Johnson,Mark A. Varney,Laszlo Urban,Rainer Kuhn +17 more
TL;DR: In this paper, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) has been found to have anti-hyperalgesic effects in models of inflammatory pain.
Journal ArticleDOI
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. (Novartic Institute for Medical Sciences, London, United Kingdom) Pain. 2001;92:91–100.
Alyson Fox,Adam Kesingland,Clive Gentry,Kara McNair,Sadhana Patel,Laszlo Urban,Iain F. James +6 more
TL;DR: Cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain and are likely to be mediated via an action in the CNS and in the periphery.
Journal ArticleDOI
Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain.
Katharine Walker,Stephen J. Medhurst,Bruce L. Kidd,Markus Glatt,Mick Bowes,Sadhana Patel,Kara McNair,Adam Kesingland,Jonathan Green,Otto Chan,Alyson Fox,Laszlo Urban +11 more
TL;DR: It is concluded that zoledronic acid, in addition to, or independent from, its anti‐metastatic and bone preserving therapeutic effects, is an anti‐nociceptive agent in a rat model of metastatic cancer pain.