Adam L. Clayton

TL;DR: Structural, functional, and evolutionary analyses indicate that SOPE has undergone extensive adaptation toward an insect-associated lifestyle in a very short time period, and analyses of the bacterial cell envelope and genes encoding secretion systems suggest that these structures and elements have become simplified in the transition to a mutualistic association.

TL;DR: This study characterized a novel opportunistic human pathogen, designated “strain HS,” and found that it is a close relative of the insect endosymbiont Sodalis glossinidius, providing compelling support for the notion that mutualists evolve from pathogenic progenitors.

TL;DR: Targeted sequencing data suggest that NPM1 mutations are a secondary or late event in the pathogenesis of AML and are preceded by founder mutations in genes that may be associated with recently described preclinical states such as clonal hematopoiesis of indeterminate potential or clonal cytopenias of undetermined significance.

TL;DR: This article showed that mutant strains of S.praecaptivus that lack genetic components of a quorum-sensing (QS) apparatus have a rapid and potent killing phenotype following microinjection into an insect host.

TL;DR: A review of the molecular updates of HHA with particular focus on the neonatal and pediatric population will focus on bilirubin‐associated neurotoxicity and its consequences.